Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012258757> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2012258757 endingPage "187" @default.
- W2012258757 startingPage "177" @default.
- W2012258757 abstract "A ten-year-old, male castrated Springer Spaniel was presented for dysphagia, ptyalism, and regurgitation. Evidence of megaesophagus and mild aspiration pneumonia were apparent on thoracic radiographs. A diagnosis of focal acquired myasthenia gravis was suspected and subsequently confirmed with a positive serum acetylcholine (ACh) receptor antibody concentration (3.87 nM/L). A gastrostomy tube was placed shortly after presentation; food and drugs (including azathioprine) were administered through the tube. After transient improvement, the dog suddenly deteriorated clinically, experiencing frequent episodes of regurgitation and developing severe aspiration pneumonia. Mycophenolate mofetil (MMF), a novel immunosuppressive drug with relative specificity for lymphocytes, was instituted every twelve hours via the gastrostomy tube. Within four days of beginning MMF therapy, both clinical evidence of pharyngeal/esophageal dysfunction and radiographic evidence of megaesophagus had resolved. Initially, clinical side-effects of combined MMF/AZA administration were not apparent, but the patient experienced several vomiting episodes during the third week of treatment. The vomiting resolved after decreasing the dose of both drugs. The patient made a full recovery, and a one-month follow-up ACh receptor antibody concentration was normal (0.26 nM/L). After one month of combination therapy, the patient was weaned off of AZA and maintained on MMF as the sole immunosuppressive drug. The dog was subsequently weaned off of MMF on two occasions. Mycophenolate mofetil was reinstituted after the first discontinuation due to the development of profound appendicular muscle weakness two days after stopping MMF; the weakness resolved within 24 hours of reinstituting MMF. A positive ACh receptor antibody concentration (0.89 nM/L) after the second MMF weaning prompted the second reinstitution of MMF. Two months following this second MMF reinstitution, the dog was again serologically negative (0.51 nM/L) for myasthenia gravis. At the time of last followup, the dog remained in clinical remission eight months after initial presentation. The use of MMF to treat acquired myasthenia gravis in dogs has not been reported previously. The literature concerning MMF and its potential use in treating patients with autoimmune diseases is discussed." @default.
- W2012258757 created "2016-06-24" @default.
- W2012258757 creator A5002088032 @default.
- W2012258757 creator A5004420952 @default.
- W2012258757 creator A5027937349 @default.
- W2012258757 creator A5034556205 @default.
- W2012258757 creator A5088973918 @default.
- W2012258757 date "2000-09-01" @default.
- W2012258757 modified "2023-09-27" @default.
- W2012258757 title "Treatment of a Myasthenic Dog with Mycophenolate Mofetil" @default.
- W2012258757 cites W1979470935 @default.
- W2012258757 cites W2009406967 @default.
- W2012258757 cites W2016100084 @default.
- W2012258757 cites W2019202710 @default.
- W2012258757 cites W2030206326 @default.
- W2012258757 cites W2037484778 @default.
- W2012258757 cites W2048911335 @default.
- W2012258757 cites W2066680723 @default.
- W2012258757 cites W2087685137 @default.
- W2012258757 cites W2094776105 @default.
- W2012258757 cites W2150064963 @default.
- W2012258757 cites W2156860515 @default.
- W2012258757 cites W2416318875 @default.
- W2012258757 cites W4248406156 @default.
- W2012258757 doi "https://doi.org/10.1111/j.1476-4431.2000.tb00009.x" @default.
- W2012258757 hasPublicationYear "2000" @default.
- W2012258757 type Work @default.
- W2012258757 sameAs 2012258757 @default.
- W2012258757 citedByCount "18" @default.
- W2012258757 countsByYear W20122587572014 @default.
- W2012258757 countsByYear W20122587572016 @default.
- W2012258757 countsByYear W20122587572018 @default.
- W2012258757 countsByYear W20122587572021 @default.
- W2012258757 crossrefType "journal-article" @default.
- W2012258757 hasAuthorship W2012258757A5002088032 @default.
- W2012258757 hasAuthorship W2012258757A5004420952 @default.
- W2012258757 hasAuthorship W2012258757A5027937349 @default.
- W2012258757 hasAuthorship W2012258757A5034556205 @default.
- W2012258757 hasAuthorship W2012258757A5088973918 @default.
- W2012258757 hasConcept C126322002 @default.
- W2012258757 hasConcept C141071460 @default.
- W2012258757 hasConcept C2776250341 @default.
- W2012258757 hasConcept C2776760755 @default.
- W2012258757 hasConcept C2777819096 @default.
- W2012258757 hasConcept C2777914695 @default.
- W2012258757 hasConcept C2778105408 @default.
- W2012258757 hasConcept C2779134260 @default.
- W2012258757 hasConcept C2780596822 @default.
- W2012258757 hasConcept C2780852908 @default.
- W2012258757 hasConcept C2781338923 @default.
- W2012258757 hasConcept C42219234 @default.
- W2012258757 hasConcept C71924100 @default.
- W2012258757 hasConcept C90924648 @default.
- W2012258757 hasConceptScore W2012258757C126322002 @default.
- W2012258757 hasConceptScore W2012258757C141071460 @default.
- W2012258757 hasConceptScore W2012258757C2776250341 @default.
- W2012258757 hasConceptScore W2012258757C2776760755 @default.
- W2012258757 hasConceptScore W2012258757C2777819096 @default.
- W2012258757 hasConceptScore W2012258757C2777914695 @default.
- W2012258757 hasConceptScore W2012258757C2778105408 @default.
- W2012258757 hasConceptScore W2012258757C2779134260 @default.
- W2012258757 hasConceptScore W2012258757C2780596822 @default.
- W2012258757 hasConceptScore W2012258757C2780852908 @default.
- W2012258757 hasConceptScore W2012258757C2781338923 @default.
- W2012258757 hasConceptScore W2012258757C42219234 @default.
- W2012258757 hasConceptScore W2012258757C71924100 @default.
- W2012258757 hasConceptScore W2012258757C90924648 @default.
- W2012258757 hasIssue "3" @default.
- W2012258757 hasLocation W20122587571 @default.
- W2012258757 hasOpenAccess W2012258757 @default.
- W2012258757 hasPrimaryLocation W20122587571 @default.
- W2012258757 hasRelatedWork W2008038414 @default.
- W2012258757 hasRelatedWork W2014435840 @default.
- W2012258757 hasRelatedWork W2062168930 @default.
- W2012258757 hasRelatedWork W2088216252 @default.
- W2012258757 hasRelatedWork W2116827274 @default.
- W2012258757 hasRelatedWork W2314457680 @default.
- W2012258757 hasRelatedWork W2320184811 @default.
- W2012258757 hasRelatedWork W2413875961 @default.
- W2012258757 hasRelatedWork W2592423080 @default.
- W2012258757 hasRelatedWork W4295539686 @default.
- W2012258757 hasVolume "10" @default.
- W2012258757 isParatext "false" @default.
- W2012258757 isRetracted "false" @default.
- W2012258757 magId "2012258757" @default.
- W2012258757 workType "article" @default.