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• W2012258936 abstract "ObjectiveTo determine whether microRNAs (miRNAs) are differentially expressed in human leiomyoma versus matched myometrial tissue.DesignMicroarray with real-time polymerase chain reaction (PCR) validation.SettingAcademic medical center.Patient(s)Premenopausal subjects (n = 15), who were undergoing hysterectomies for leiomyoma-related symptoms.Intervention(s)None.Main Outcome Measure(s)Statistically differential expression of miRNAs in leiomyoma versus myometrium.Result(s)Forty-six miRNA species were differentially expressed in leiomyoma versus normal myometrium. Of these, 19 were overexpressed and 27 were underexpressed in leiomyomas. The changes ranged from 1.2-fold to 11.8-fold. These findings were confirmed using real-time reverse transcriptase PCR for selected miRNAs (miRNAs 21, 34a, 125b, 139, and 323).Conclusion(s)Our findings indicate that miRNAs are differentially expressed between human leiomyoma and matched myometrium. Given this differential expression, miRNAs may play a role in the pathogenesis of uterine leiomyoma and may serve as future therapeutic targets for the treatment of these tumors. To determine whether microRNAs (miRNAs) are differentially expressed in human leiomyoma versus matched myometrial tissue. Microarray with real-time polymerase chain reaction (PCR) validation. Academic medical center. Premenopausal subjects (n = 15), who were undergoing hysterectomies for leiomyoma-related symptoms. None. Statistically differential expression of miRNAs in leiomyoma versus myometrium. Forty-six miRNA species were differentially expressed in leiomyoma versus normal myometrium. Of these, 19 were overexpressed and 27 were underexpressed in leiomyomas. The changes ranged from 1.2-fold to 11.8-fold. These findings were confirmed using real-time reverse transcriptase PCR for selected miRNAs (miRNAs 21, 34a, 125b, 139, and 323). Our findings indicate that miRNAs are differentially expressed between human leiomyoma and matched myometrium. Given this differential expression, miRNAs may play a role in the pathogenesis of uterine leiomyoma and may serve as future therapeutic targets for the treatment of these tumors." @default.
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• W2012258936 date "2008-06-01" @default.
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• W2012258936 title "Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium" @default.
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• W2012258936 doi "https://doi.org/10.1016/j.fertnstert.2007.05.074" @default.
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