FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012259207> ?p ?o ?g. }

• W2012259207 endingPage "3070" @default.
• W2012259207 startingPage "3060" @default.
• W2012259207 abstract "Antiangiogenic cancer therapy based on nanoparticulate drug delivery systems (nano-DDS) is emerging as a promising new approach besides the proved molecular-targeted antiangiogenic agents. The current nano-DDS are restricted to the targeting to tumor vascular endothelial cells, but seldom efforts have been made to target the tumor vascular pericytes which are also actively involved in tumor angiogenesis. In this study, we developed a new nano-DDS, TH10 peptide (TAASGVRSMH) conjugated nanoparticles loading docetaxel (TH10-DTX-NP) that can target the NG2 proteoglycan highly expressed in tumor vascular pericytes, for the investigation of therapeutic efficacy in the mice bearing B16F10-luc-G5 melanoma experimental lung metastasis. The results demonstrated that TH10-DTX-NP achieved controlled drug release in PBS and the mixture of rat plasma and PBS (1:1, v/v), and exhibited favorable in vivo long-circulating feature. TH10 peptide conjugation facilitated the nanoparticle internalization in pericytes via the interaction between TH10 and NG2 receptor, leading to more inhibition of pericyte viability and migration. TH10-conjugated nanoparticles could accurately target the vascular pericytes of B16F10-luc-G5 lung metastasis, where DTX-induced pronounceable pericyte apoptosis. TH10-DTX-NP significantly prolonged the mice survival with no obvious toxicity, and this enhanced antitumor effect was closely related with the decreased pericyte density and microvessel density in the lung metastases. The present research reveals the potency and significance of targeting tumor vascular pericytes using nano-DDS in antiangiogenic cancer therapy." @default.
• W2012259207 created "2016-06-24" @default.
• W2012259207 creator A5002855077 @default.
• W2012259207 creator A5026153335 @default.
• W2012259207 creator A5036900255 @default.
• W2012259207 creator A5037979381 @default.
• W2012259207 creator A5038663670 @default.
• W2012259207 creator A5046249498 @default.
• W2012259207 creator A5049845417 @default.
• W2012259207 creator A5055838753 @default.
• W2012259207 creator A5066058965 @default.
• W2012259207 creator A5090176999 @default.
• W2012259207 date "2014-03-01" @default.
• W2012259207 modified "2023-10-18" @default.
• W2012259207 title "Selective eradication of tumor vascular pericytes by peptide-conjugated nanoparticles for antiangiogenic therapy of melanoma lung metastasis" @default.
• W2012259207 cites W1975058097 @default.
• W2012259207 cites W1978611909 @default.
• W2012259207 cites W1989957765 @default.
• W2012259207 cites W1991716060 @default.
• W2012259207 cites W1999600810 @default.
• W2012259207 cites W2014339619 @default.
• W2012259207 cites W2014996434 @default.
• W2012259207 cites W2017322644 @default.
• W2012259207 cites W2027011993 @default.
• W2012259207 cites W2037312364 @default.
• W2012259207 cites W2049385358 @default.
• W2012259207 cites W2052734417 @default.
• W2012259207 cites W2058879480 @default.
• W2012259207 cites W2059954427 @default.
• W2012259207 cites W2064706547 @default.
• W2012259207 cites W2066907008 @default.
• W2012259207 cites W2082242545 @default.
• W2012259207 cites W2084122259 @default.
• W2012259207 cites W2097350641 @default.
• W2012259207 cites W2111436238 @default.
• W2012259207 cites W2111691542 @default.
• W2012259207 cites W2112940666 @default.
• W2012259207 cites W2124784163 @default.
• W2012259207 cites W2131900949 @default.
• W2012259207 cites W2137541604 @default.
• W2012259207 cites W2143852804 @default.
• W2012259207 cites W2151460035 @default.
• W2012259207 cites W2155201844 @default.
• W2012259207 cites W2756717034 @default.
• W2012259207 cites W4253705647 @default.
• W2012259207 doi "https://doi.org/10.1016/j.biomaterials.2013.12.027" @default.
• W2012259207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24393268" @default.
• W2012259207 hasPublicationYear "2014" @default.
• W2012259207 type Work @default.
• W2012259207 sameAs 2012259207 @default.
• W2012259207 citedByCount "57" @default.
• W2012259207 countsByYear W20122592072014 @default.
• W2012259207 countsByYear W20122592072015 @default.
• W2012259207 countsByYear W20122592072016 @default.
• W2012259207 countsByYear W20122592072017 @default.
• W2012259207 countsByYear W20122592072018 @default.
• W2012259207 countsByYear W20122592072019 @default.
• W2012259207 countsByYear W20122592072020 @default.
• W2012259207 countsByYear W20122592072021 @default.
• W2012259207 countsByYear W20122592072022 @default.
• W2012259207 countsByYear W20122592072023 @default.
• W2012259207 crossrefType "journal-article" @default.
• W2012259207 hasAuthorship W2012259207A5002855077 @default.
• W2012259207 hasAuthorship W2012259207A5026153335 @default.
• W2012259207 hasAuthorship W2012259207A5036900255 @default.
• W2012259207 hasAuthorship W2012259207A5037979381 @default.
• W2012259207 hasAuthorship W2012259207A5038663670 @default.
• W2012259207 hasAuthorship W2012259207A5046249498 @default.
• W2012259207 hasAuthorship W2012259207A5049845417 @default.
• W2012259207 hasAuthorship W2012259207A5055838753 @default.
• W2012259207 hasAuthorship W2012259207A5066058965 @default.
• W2012259207 hasAuthorship W2012259207A5090176999 @default.
• W2012259207 hasConcept C121608353 @default.
• W2012259207 hasConcept C123012128 @default.
• W2012259207 hasConcept C126322002 @default.
• W2012259207 hasConcept C202751555 @default.
• W2012259207 hasConcept C2777658100 @default.
• W2012259207 hasConcept C2779013556 @default.
• W2012259207 hasConcept C2780394083 @default.
• W2012259207 hasConcept C2780427682 @default.
• W2012259207 hasConcept C502942594 @default.
• W2012259207 hasConcept C55493867 @default.
• W2012259207 hasConcept C71924100 @default.
• W2012259207 hasConcept C86803240 @default.
• W2012259207 hasConceptScore W2012259207C121608353 @default.
• W2012259207 hasConceptScore W2012259207C123012128 @default.
• W2012259207 hasConceptScore W2012259207C126322002 @default.
• W2012259207 hasConceptScore W2012259207C202751555 @default.
• W2012259207 hasConceptScore W2012259207C2777658100 @default.
• W2012259207 hasConceptScore W2012259207C2779013556 @default.
• W2012259207 hasConceptScore W2012259207C2780394083 @default.
• W2012259207 hasConceptScore W2012259207C2780427682 @default.
• W2012259207 hasConceptScore W2012259207C502942594 @default.
• W2012259207 hasConceptScore W2012259207C55493867 @default.
• W2012259207 hasConceptScore W2012259207C71924100 @default.
• W2012259207 hasConceptScore W2012259207C86803240 @default.
• W2012259207 hasFunder F4320321001 @default.
• W2012259207 hasFunder F4320321885 @default.

• next