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• W2012271289 abstract "Cerebellar climbing fibers (CFs) provide powerful excitatory input to Purkinje cells (PCs), which represent the sole output of the cerebellar cortex. Recent discoveries suggest that CFs have information-rich signaling properties important for cerebellar function, beyond eliciting the well known all-or-none PC complex spike. CF morphology has not been quantitatively analyzed at the same level of detail as its biophysical properties. Because morphology can greatly influence function, including the capacity for information processing, it is important to understand CF branching structure in detail, as well as its variability across and within arbors. We have digitally reconstructed 68 rat CFs labeled using biotinylated dextran amine injected into the inferior olive and comprehensively quantified their morphology. CF structure was considerably diverse even within the same anatomical regions. Distinctly identifiable primary, tendril, and distal branches could be operationally differentiated by the relative size of the subtrees at their initial bifurcations. Additionally, primary branches were more directed toward the cortical surface and had fewer and less pronounced synaptic boutons, suggesting they prioritize efficient and reliable signal propagation. Tendril and distal branches were spatially segregated and bouton dense, indicating specialization in signal transmission. Furthermore, CFs systematically targeted molecular layer interneuron cell bodies, especially at terminal boutons, potentially instantiating feedforward inhibition on PCs. This study offers the most detailed and comprehensive characterization of CF morphology to date. The reconstruction files and metadata are publicly distributed at NeuroMorpho.org." @default.
• W2012271289 created "2016-06-24" @default.
• W2012271289 creator A5045923034 @default.
• W2012271289 creator A5085805354 @default.
• W2012271289 creator A5087672831 @default.
• W2012271289 creator A5091044736 @default.
• W2012271289 date "2012-10-17" @default.
• W2012271289 modified "2023-10-12" @default.
• W2012271289 title "Digital Morphometry of Rat Cerebellar Climbing Fibers Reveals Distinct Branch and Bouton Types" @default.
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• W2012271289 doi "https://doi.org/10.1523/jneurosci.2018-12.2012" @default.
• W2012271289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3492941" @default.
• W2012271289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23077053" @default.
• W2012271289 hasPublicationYear "2012" @default.
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