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• W2012286726 abstract "Demand for oral alternatives to parenteral delivery has led to renewed interest in excipient-like intestinal permeation enhancers that improve oral drug bioavailability. Oral delivery of macromolecules including peptides and proteins is limited by pre-systemic degradation and poor penetration across the gut wall. Research on oral absorption enhancers that increase gut permeability was first undertaken 50 years ago, yet clinical success has yet to be achieved. Development has been hampered by lack of adequate reproducible efficacy as well as perceived safety concerns. We review some selected permeation-enhancing excipients that are key components of peptide formulations in advanced clinical development and assess why translation of such technologies is close to fruition." @default.
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• W2012286726 date "2012-06-01" @default.
• W2012286726 modified "2023-10-10" @default.
• W2012286726 title "Overcoming poor permeability: translating permeation enhancers for oral peptide delivery" @default.
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• W2012286726 doi "https://doi.org/10.1016/j.ddtec.2011.11.006" @default.
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