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- W2012288345 abstract "DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for δ opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a dose-related increase in spectral power and HVSA (peak frequency of 5.0 Hz) during behavioral stupor, and a theta driving (5.25-8.0 Hz) associated with intense behavioral arousal. These effects were antagonized by high (10 mg/kg), but not low (1.0 mg/kg), doses of naloxone. Both analogs failed to cause EEG or convulsive seizures. In contrast, i.c.v. administration of DADLE ([D-Ala2, D-Leu5]-Enkephalin), an enkephalin analog with activity at both μ and δ binding sites, caused initial nonconvulsive EEG seizures followed by HVSA (3.0 Hz); theta driving was not evident. The incidence of the seizures was dose-related and antagonized by very low doses of naloxone (0.01-1.0 mg/kg). Collectively, the inability of DPDPE and DPLPE to cause seizure activity, and the marked sensitivity of DADLE-induced EEG seizures to naloxone, suggest that δ receptors are not directly responsible for DADLE-induced EEG seizure activity. Furthermore, these data implicate μ opioid receptors as the primary sites responsible for enkephalin-induced seizures." @default.
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- W2012288345 date "1984-12-01" @default.
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- W2012288345 title "Electroencephalographic assessment of the role of δ receptors in opioid peptide - induced seizures" @default.
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- W2012288345 doi "https://doi.org/10.1016/0143-4179(84)90065-9" @default.
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