Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012288767> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2012288767 endingPage "74" @default.
- W2012288767 startingPage "74" @default.
- W2012288767 abstract "To evaluate the possible additivity of the effects of latanoprost and 8-iso prostaglandin E2 (8-iso PGE2) on intraocular pressure (IOP) in monkey eyes with laser-induced glaucoma.The IOP was measured hourly for 6 hours beginning at 9:30 AM on day 1 (baseline day), days 6 and 7 (single-agent therapy), and days 13 and 14 (combination therapy with both agents). Following 1 day of baseline measurement, 4 monkeys with unilateral glaucoma received monotherapy) twice daily with either 1 drop of 0.005% latanoprost, or 0.1% 8-iso PGE2, 25 microL, at 9:30 AM and 3:30 PM from days 2 through 7. From days 8 through 14, both agents were applied twice daily 5 minutes apart.The maximum reduction of IOP (mean +/- SEM) was 8.8 +/- 1.9 mmHg (26%) (P<.05) with latanoprost alone and 6.5 +/- 1.0 mmHg (21%) (P<.0l) with 8-iso PGE2 alone, 2 hours after the morning dosing on day 7. A further reduction of IOP of 4.0 +/- 0.6 mm Hg was produced when 8-iso PGE2 was added to latanoprost and of 3.0 +/- 0.7 mm Hg was produced when latanoprost was added to 8-iso PGE2 on day 13 before the morning dosing. Combination therapy with both agents caused maximum IOP reductions from baseline of 11.3 +/- 3.0 mm Hg (33%) (P<.05) (latanoprost with 8-iso PGE2 added) and of 9.8 +/- 1.3 mm Hg (31%) (P<.01) (8-iso PGE2 with latanoprost added) on day 14.Latanoprost and 8-iso PGE2 have an additive effect on IOP in glaucomatous monkey eyes.At least 50% of patients are treated with more than 1 ocular hypotensive medication. Thus, the determination of the additive effects on IOP of glaucoma medications will help to define optimum treatment regimens." @default.
- W2012288767 created "2016-06-24" @default.
- W2012288767 creator A5001955385 @default.
- W2012288767 creator A5012671046 @default.
- W2012288767 creator A5013459699 @default.
- W2012288767 creator A5037228782 @default.
- W2012288767 creator A5054435515 @default.
- W2012288767 creator A5063794517 @default.
- W2012288767 date "2000-01-01" @default.
- W2012288767 modified "2023-09-27" @default.
- W2012288767 title "Effect of Latanoprost or 8-iso Prostaglandin E2 Alone and in Combination on Intraocular Pressure in Glaucomatous Monkey Eyes" @default.
- W2012288767 cites W1524686653 @default.
- W2012288767 cites W1994014846 @default.
- W2012288767 cites W2006726419 @default.
- W2012288767 cites W2040344985 @default.
- W2012288767 cites W2041009121 @default.
- W2012288767 cites W2062090813 @default.
- W2012288767 cites W2074807464 @default.
- W2012288767 cites W2076260416 @default.
- W2012288767 cites W71395560 @default.
- W2012288767 doi "https://doi.org/10.1001/archopht.118.1.74" @default.
- W2012288767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10636418" @default.
- W2012288767 hasPublicationYear "2000" @default.
- W2012288767 type Work @default.
- W2012288767 sameAs 2012288767 @default.
- W2012288767 citedByCount "13" @default.
- W2012288767 countsByYear W20122887672012 @default.
- W2012288767 crossrefType "journal-article" @default.
- W2012288767 hasAuthorship W2012288767A5001955385 @default.
- W2012288767 hasAuthorship W2012288767A5012671046 @default.
- W2012288767 hasAuthorship W2012288767A5013459699 @default.
- W2012288767 hasAuthorship W2012288767A5037228782 @default.
- W2012288767 hasAuthorship W2012288767A5054435515 @default.
- W2012288767 hasAuthorship W2012288767A5063794517 @default.
- W2012288767 hasBestOaLocation W20122887671 @default.
- W2012288767 hasConcept C118487528 @default.
- W2012288767 hasConcept C126322002 @default.
- W2012288767 hasConcept C19720800 @default.
- W2012288767 hasConcept C2776740260 @default.
- W2012288767 hasConcept C2777288759 @default.
- W2012288767 hasConcept C2777625524 @default.
- W2012288767 hasConcept C2778527774 @default.
- W2012288767 hasConcept C2779526769 @default.
- W2012288767 hasConcept C2780664492 @default.
- W2012288767 hasConcept C2781092963 @default.
- W2012288767 hasConcept C71924100 @default.
- W2012288767 hasConceptScore W2012288767C118487528 @default.
- W2012288767 hasConceptScore W2012288767C126322002 @default.
- W2012288767 hasConceptScore W2012288767C19720800 @default.
- W2012288767 hasConceptScore W2012288767C2776740260 @default.
- W2012288767 hasConceptScore W2012288767C2777288759 @default.
- W2012288767 hasConceptScore W2012288767C2777625524 @default.
- W2012288767 hasConceptScore W2012288767C2778527774 @default.
- W2012288767 hasConceptScore W2012288767C2779526769 @default.
- W2012288767 hasConceptScore W2012288767C2780664492 @default.
- W2012288767 hasConceptScore W2012288767C2781092963 @default.
- W2012288767 hasConceptScore W2012288767C71924100 @default.
- W2012288767 hasIssue "1" @default.
- W2012288767 hasLocation W20122887671 @default.
- W2012288767 hasLocation W20122887672 @default.
- W2012288767 hasOpenAccess W2012288767 @default.
- W2012288767 hasPrimaryLocation W20122887671 @default.
- W2012288767 hasRelatedWork W1584947910 @default.
- W2012288767 hasRelatedWork W1973757121 @default.
- W2012288767 hasRelatedWork W1999101048 @default.
- W2012288767 hasRelatedWork W2012288767 @default.
- W2012288767 hasRelatedWork W2029271825 @default.
- W2012288767 hasRelatedWork W2046688990 @default.
- W2012288767 hasRelatedWork W2083699796 @default.
- W2012288767 hasRelatedWork W2992206843 @default.
- W2012288767 hasRelatedWork W4304813480 @default.
- W2012288767 hasRelatedWork W882515243 @default.
- W2012288767 hasVolume "118" @default.
- W2012288767 isParatext "false" @default.
- W2012288767 isRetracted "false" @default.
- W2012288767 magId "2012288767" @default.
- W2012288767 workType "article" @default.