FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012290878> ?p ?o ?g. }

• W2012290878 endingPage "102" @default.
• W2012290878 startingPage "98" @default.
• W2012290878 abstract "Felotaxel (SHR110008), currently under clinical investigation in phase I trial, is a new taxane with potent antitumor effects. The purpose of this research was to evaluate the pharmacokinetic profiles of felotaxel in rats and the protein binding in plasma. Data were collated from several preclinical investigations, where the plasma pharmacokinetics, tissue distribution and excretion of felotaxel were assessed after a single intravenous (i.v.) injection (5 mg/kg) to rats. Samples felotaxel concentration was determined by a LC-MS/MS method. The plasma concentration versus time data was analyzed non-compartmental model. Plasma protein binding was assessed using ultrafiltration. Pharmacokinetic properties of felotaxel were similar to the previous data from the rats. Felotaxel was rapidly distributed to normal tissues, drug concentrations in the tissues tested except the brain were two to eight times higher than those in plasma, but half-lives and mean residence times were similar. The kidneys manifested as the dominant organs with high exposure that might be responsible for elimination of felotaxel. Approximately 0.21% and 0.72% of felotaxel was excreted via the urine and feces within 24 h; 0.25% was excreted into the bile up to 12 h after a single dose. The protein binding ability of felotaxel with concentration 100–5000 ng/mL in the plasma was nearly linear. This study first provided the full absorption, distribution, and excretion characteristics of felotaxel, which would be helpful for its clinical regiment design." @default.
• W2012290878 created "2016-06-24" @default.
• W2012290878 creator A5012907699 @default.
• W2012290878 creator A5015514957 @default.
• W2012290878 creator A5017160894 @default.
• W2012290878 creator A5017799074 @default.
• W2012290878 creator A5028072152 @default.
• W2012290878 creator A5029660382 @default.
• W2012290878 creator A5044296302 @default.
• W2012290878 creator A5055423740 @default.
• W2012290878 creator A5072884880 @default.
• W2012290878 creator A5075430732 @default.
• W2012290878 date "2012-03-01" @default.
• W2012290878 modified "2023-10-16" @default.
• W2012290878 title "Preclinical pharmacokinetic analysis of felotaxel (SHR110008), a novel derivative of docetaxel, in rats and its protein binding ability in vitro" @default.
• W2012290878 cites W1919316818 @default.
• W2012290878 cites W1968785826 @default.
• W2012290878 cites W2000433012 @default.
• W2012290878 cites W2014184691 @default.
• W2012290878 cites W2037671642 @default.
• W2012290878 cites W2041580580 @default.
• W2012290878 cites W2066522045 @default.
• W2012290878 cites W2081174475 @default.
• W2012290878 cites W2101100140 @default.
• W2012290878 cites W2112443004 @default.
• W2012290878 cites W2136277895 @default.
• W2012290878 cites W2137303860 @default.
• W2012290878 cites W2180967442 @default.
• W2012290878 cites W2740368365 @default.
• W2012290878 cites W4249987421 @default.
• W2012290878 doi "https://doi.org/10.1016/j.biopha.2011.11.012" @default.
• W2012290878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22264880" @default.
• W2012290878 hasPublicationYear "2012" @default.
• W2012290878 type Work @default.
• W2012290878 sameAs 2012290878 @default.
• W2012290878 citedByCount "6" @default.
• W2012290878 countsByYear W20122908782012 @default.
• W2012290878 countsByYear W20122908782016 @default.
• W2012290878 countsByYear W20122908782017 @default.
• W2012290878 countsByYear W20122908782020 @default.
• W2012290878 countsByYear W20122908782021 @default.
• W2012290878 crossrefType "journal-article" @default.
• W2012290878 hasAuthorship W2012290878A5012907699 @default.
• W2012290878 hasAuthorship W2012290878A5015514957 @default.
• W2012290878 hasAuthorship W2012290878A5017160894 @default.
• W2012290878 hasAuthorship W2012290878A5017799074 @default.
• W2012290878 hasAuthorship W2012290878A5028072152 @default.
• W2012290878 hasAuthorship W2012290878A5029660382 @default.
• W2012290878 hasAuthorship W2012290878A5044296302 @default.
• W2012290878 hasAuthorship W2012290878A5055423740 @default.
• W2012290878 hasAuthorship W2012290878A5072884880 @default.
• W2012290878 hasAuthorship W2012290878A5075430732 @default.
• W2012290878 hasConcept C10146269 @default.
• W2012290878 hasConcept C110121322 @default.
• W2012290878 hasConcept C112705442 @default.
• W2012290878 hasConcept C121332964 @default.
• W2012290878 hasConcept C125287762 @default.
• W2012290878 hasConcept C134306372 @default.
• W2012290878 hasConcept C146543888 @default.
• W2012290878 hasConcept C185592680 @default.
• W2012290878 hasConcept C202751555 @default.
• W2012290878 hasConcept C24890656 @default.
• W2012290878 hasConcept C2780026642 @default.
• W2012290878 hasConcept C33923547 @default.
• W2012290878 hasConcept C51639874 @default.
• W2012290878 hasConcept C55493867 @default.
• W2012290878 hasConcept C71924100 @default.
• W2012290878 hasConcept C98274493 @default.
• W2012290878 hasConceptScore W2012290878C10146269 @default.
• W2012290878 hasConceptScore W2012290878C110121322 @default.
• W2012290878 hasConceptScore W2012290878C112705442 @default.
• W2012290878 hasConceptScore W2012290878C121332964 @default.
• W2012290878 hasConceptScore W2012290878C125287762 @default.
• W2012290878 hasConceptScore W2012290878C134306372 @default.
• W2012290878 hasConceptScore W2012290878C146543888 @default.
• W2012290878 hasConceptScore W2012290878C185592680 @default.
• W2012290878 hasConceptScore W2012290878C202751555 @default.
• W2012290878 hasConceptScore W2012290878C24890656 @default.
• W2012290878 hasConceptScore W2012290878C2780026642 @default.
• W2012290878 hasConceptScore W2012290878C33923547 @default.
• W2012290878 hasConceptScore W2012290878C51639874 @default.
• W2012290878 hasConceptScore W2012290878C55493867 @default.
• W2012290878 hasConceptScore W2012290878C71924100 @default.
• W2012290878 hasConceptScore W2012290878C98274493 @default.
• W2012290878 hasIssue "2" @default.
• W2012290878 hasLocation W20122908781 @default.
• W2012290878 hasLocation W20122908782 @default.
• W2012290878 hasOpenAccess W2012290878 @default.
• W2012290878 hasPrimaryLocation W20122908781 @default.
• W2012290878 hasRelatedWork W1709858528 @default.
• W2012290878 hasRelatedWork W2049819497 @default.
• W2012290878 hasRelatedWork W2057258661 @default.
• W2012290878 hasRelatedWork W2159604065 @default.
• W2012290878 hasRelatedWork W2326289847 @default.
• W2012290878 hasRelatedWork W2377321769 @default.
• W2012290878 hasRelatedWork W2378109603 @default.
• W2012290878 hasRelatedWork W297699154 @default.
• W2012290878 hasRelatedWork W3120625362 @default.

• next