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- W2012291736 abstract "Kinetic analysis of 3H-serotonin accumulation by crude synaptosomal suspensions of neocortex, hippocampus and caudate or by whole homogenates of cerebellum revealed the presence of a high affinity uptake component having an apparent Km for serotonin which ranged from 2.8 to 6.0 × 10−8 M. A second, low affinity, uptake component with an apparent Km of 7 × 10−6 M was present in caudate. A comparable low affinity uptake component for serotonin was not observed in neocortex, hippocampus or cerebellum. Lesions in the medial forebrain bundle produced significant decreases in serotonin comtent of neocortes, hippocampus and caudate (66 to 75%) and a significant increase in serotonin content of cerebellum (25%). The lesions did not affect the apparent Km of the high affinity uptake system but did produce change in Vmax which paralleled the changes in content of serotonin. The lesions also produced decreases in dopamine and norepinephrine content of caudate and a comparable decrease in the Vmax of the low affinity uptake system with no change in the apparent Km. There was a correlation of 0.97 between the endogenous content of serotonin and the Vmax of the high affinity uptake system. These results support the view that the high and low affinity components of serotonin uptake represent accumulation into serotonergic and catecholaminergic neurons, respectively." @default.
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- W2012291736 title "Kinetic analysis of 3H-serotonin accumulation in four regions of rat brain after lesions in the medial forebrain bundle" @default.
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- W2012291736 doi "https://doi.org/10.1016/0024-3205(76)90380-5" @default.
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