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• W2012300945 startingPage "1009" @default.
• W2012300945 abstract "The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc finger protein of unknown function. Association of the BRCA1 protein with the DNA repair protein Rad51 and changes in the phosphorylation and cellular localization of the protein after exposure to DNA-damaging agents are consistent with a role for BRCA1 in DNA repair. Here, it is shown that mouse embryonic stem cells deficient in BRCA1 are defective in the ability to carry out transcription-coupled repair of oxidative DNA damage, and are hypersensitive to ionizing radiation and hydrogen peroxide. These results suggest that BRCA1 participates, directly or indirectly, in transcription-coupled repair of oxidative DNA damage." @default.
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• W2012300945 date "1998-08-14" @default.
• W2012300945 modified "2023-10-18" @default.
• W2012300945 title "BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage" @default.
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• W2012300945 doi "https://doi.org/10.1126/science.281.5379.1009" @default.
• W2012300945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9703501" @default.
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