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- W2012302327 abstract "Previous work demonstrating the presence and differential distribution of Ca2+-binding proteins in the CNS has led to the proposal that cytosolic proteins, such as calbindin-D28k (CB), may play a pivotal role in neurons. We have used a retrovirus containing the full-length cDNA for CB to transfect the pituitary tumor cell line GH3, to generate CB-expressing GH3 cells and to investigate whether ionic channel activities as well as the concentration of intracellular free Ca2+ ([Ca2+]i) homeostasis could be altered by the presence of this Ca2+-binding protein. We show that CB-transfected GH3 cells exhibited lower Ca2+ entry through voltage-dependent Ca2+ channels and were better able to reduce [Ca2+]i transients evoked by voltage depolarizations than the wild-type parent cell line. These observations provide a mechanism by which CB may protect tissues against Ca2+-mediated excitotoxicity." @default.
- W2012302327 created "2016-06-24" @default.
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- W2012302327 date "1992-11-01" @default.
- W2012302327 modified "2023-10-16" @default.
- W2012302327 title "Stable transfection of calbindin-D28k into the GH3 cell line alters calcium currents and intracellular calcium homeostasis" @default.
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- W2012302327 doi "https://doi.org/10.1016/0896-6273(92)90246-a" @default.
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