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- W2012303532 startingPage "763" @default.
- W2012303532 abstract "Linking synaptic plasticity with behavioral learning requires understanding how synaptic efficacy influences postsynaptic firing in neurons whose role in behavior is understood. Here, we examine plasticity at a candidate site of motor learning: vestibular nerve synapses onto neurons that mediate reflexive movements. Pairing nerve activity with changes in postsynaptic voltage induced bidirectional synaptic plasticity in vestibular nucleus projection neurons: long-term potentiation relied on calcium-permeable AMPA receptors and postsynaptic hyperpolarization, whereas long-term depression relied on NMDA receptors and postsynaptic depolarization. Remarkably, both forms of plasticity uniformly scaled synaptic currents evoked by pulse trains, and these changes in synaptic efficacy were translated into linear increases or decreases in postsynaptic firing responses. Synapses onto local inhibitory neurons were also plastic but expressed only long-term depression. Bidirectional, linear gain control of vestibular nerve synapses onto projection neurons provides a plausible mechanism for motor learning underlying adaptation of vestibular reflexes." @default.
- W2012303532 created "2016-06-24" @default.
- W2012303532 creator A5011843894 @default.
- W2012303532 creator A5060324298 @default.
- W2012303532 creator A5087053208 @default.
- W2012303532 creator A5087353199 @default.
- W2012303532 date "2010-11-01" @default.
- W2012303532 modified "2023-10-18" @default.
- W2012303532 title "Bidirectional Plasticity Gated by Hyperpolarization Controls the Gain of Postsynaptic Firing Responses at Central Vestibular Nerve Synapses" @default.
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- W2012303532 doi "https://doi.org/10.1016/j.neuron.2010.09.025" @default.
- W2012303532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3189222" @default.
- W2012303532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21092864" @default.
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