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• W2012303902 abstract "It is known that PKC is differently expressed in brain and the peripheral nervous system and is involved in cellular differentiation. We have analyzed 9 human neuronal-derived crest-cell lines for PKC-alpha mRNA. Seven out of nine expressed 9.0 kb and 4.0 kb PKC-alpha mRNAs, but three had high level of 9.0 kb transcription. The different expression of the two messenger RNAs may result from alternative splicing and a different degree of cell maturation. The same cell lines were studied for MYCN gene expression. A possible relation between the two genes is discussed. One cell line expressing high levels of both PKC-alpha mRNA was treated with 10(-5) M retinoic acid (RA). The expression of both messenger RNAs was suppressed when the cells achieved a morphological differentiation and showed neurite-like processes. A decrease of PKC-alpha gene expression was associated to down regulation of MYCN mRNA. These preliminary results suggest that PKC suppression of PKC-alpha mRNA is associated with reversion of the malignant phenotype." @default.
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• W2012303902 date "1991-03-25" @default.
• W2012303902 modified "2023-09-25" @default.
• W2012303902 title "Expression of protein kinase C-alpha (PKC-α) and MYCN mRNAs in human neuroblastoma cells and modulation during morphological differentiation induced by retinoic acid" @default.
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• W2012303902 doi "https://doi.org/10.1016/0014-5793(91)80297-g" @default.
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