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• W2012305590 abstract "The constant decline in drug discovery productivity despite the continuous growth in R&D investments has been on the table for many years and is driving changes in the current business model. We have focused our attention on what appears to be by far the major cause of attrition, the intrinsic quality of drug candidates; with the assumption that candidate quality can be designed and assessed at a rather early stage in drug discovery we have developed tools such as CNS chemical space mapping through PLS analysis, Drug Efficiency (DRUG(eff)) and the mechanistic PK/PD hypothesis. We also introduced best practices that were found extremely valuable which will be discussed in this article." @default.
• W2012305590 created "2016-06-24" @default.
• W2012305590 creator A5006377505 @default.
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• W2012305590 date "2011-10-01" @default.
• W2012305590 modified "2023-10-01" @default.
• W2012305590 title "Quality by Design in lead optimization: a new strategy to address productivity in drug discovery" @default.
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• W2012305590 doi "https://doi.org/10.1016/j.coph.2011.05.004" @default.
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