Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012306172> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2012306172 endingPage "594" @default.
- W2012306172 startingPage "589" @default.
- W2012306172 abstract "The extra-embryonic yolk sac contains adjacent layers of mesoderm and visceral endoderm. The mesodermal layer serves as the first site of embryonic hematopoiesis, while the visceral endoderm provides a means of exchanging nutrients and waste until the development of the chorioallantoic placenta. While defects in chorioallantoic fusion and yolk sac hematopoiesis have been described in Cdx mutant mouse models, little is known about the gene targets and molecular mechanisms through which Cdx members regulate these processes. To this end, we used RNA-seq to examine Cdx-dependent gene expression changes in the yolk sac. We find that loss of Cdx function impacts the expression of genes involved in yolk sac hematopoiesis, as previously described, as well as novel Cdx2 target genes. In addition, we observed Cdx-dependent changes in PRC2 subunit expression accompanied by altered H3K27me3 deposition at a subset of Cdx target genes as early as E7.5 in the embryo proper. This study identifies additional Cdx target genes and provides further evidence for Cdx-dependent epigenetic regulation of gene expression in the early embryo, and that this regulation is required to maintain gene expression programs in the extra-embryonic yolk sac at later developmental stages." @default.
- W2012306172 created "2016-06-24" @default.
- W2012306172 creator A5084032386 @default.
- W2012306172 date "1997-07-01" @default.
- W2012306172 modified "2023-09-23" @default.
- W2012306172 title "Lysosomes and teratogenesis: From hypothesis to dogma and back" @default.
- W2012306172 cites W1969730924 @default.
- W2012306172 cites W1984150694 @default.
- W2012306172 cites W1987837682 @default.
- W2012306172 cites W1990349040 @default.
- W2012306172 cites W2010056889 @default.
- W2012306172 cites W2038879985 @default.
- W2012306172 cites W2054755401 @default.
- W2012306172 cites W2056265684 @default.
- W2012306172 cites W2060205793 @default.
- W2012306172 cites W2066548011 @default.
- W2012306172 cites W2069645886 @default.
- W2012306172 cites W2094681299 @default.
- W2012306172 cites W2100523061 @default.
- W2012306172 cites W2117001073 @default.
- W2012306172 cites W2127837889 @default.
- W2012306172 cites W2133899321 @default.
- W2012306172 cites W2139465861 @default.
- W2012306172 cites W2993062588 @default.
- W2012306172 cites W621452571 @default.
- W2012306172 cites W1980241122 @default.
- W2012306172 doi "https://doi.org/10.1016/s0890-6238(97)89178-2" @default.
- W2012306172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9241680" @default.
- W2012306172 hasPublicationYear "1997" @default.
- W2012306172 type Work @default.
- W2012306172 sameAs 2012306172 @default.
- W2012306172 citedByCount "7" @default.
- W2012306172 countsByYear W20123061722017 @default.
- W2012306172 countsByYear W20123061722022 @default.
- W2012306172 countsByYear W20123061722023 @default.
- W2012306172 crossrefType "journal-article" @default.
- W2012306172 hasAuthorship W2012306172A5084032386 @default.
- W2012306172 hasConcept C104317684 @default.
- W2012306172 hasConcept C145103041 @default.
- W2012306172 hasConcept C150194340 @default.
- W2012306172 hasConcept C165864922 @default.
- W2012306172 hasConcept C196843134 @default.
- W2012306172 hasConcept C2777043721 @default.
- W2012306172 hasConcept C2777164004 @default.
- W2012306172 hasConcept C2779329299 @default.
- W2012306172 hasConcept C2780915607 @default.
- W2012306172 hasConcept C41091548 @default.
- W2012306172 hasConcept C54355233 @default.
- W2012306172 hasConcept C86803240 @default.
- W2012306172 hasConcept C95444343 @default.
- W2012306172 hasConceptScore W2012306172C104317684 @default.
- W2012306172 hasConceptScore W2012306172C145103041 @default.
- W2012306172 hasConceptScore W2012306172C150194340 @default.
- W2012306172 hasConceptScore W2012306172C165864922 @default.
- W2012306172 hasConceptScore W2012306172C196843134 @default.
- W2012306172 hasConceptScore W2012306172C2777043721 @default.
- W2012306172 hasConceptScore W2012306172C2777164004 @default.
- W2012306172 hasConceptScore W2012306172C2779329299 @default.
- W2012306172 hasConceptScore W2012306172C2780915607 @default.
- W2012306172 hasConceptScore W2012306172C41091548 @default.
- W2012306172 hasConceptScore W2012306172C54355233 @default.
- W2012306172 hasConceptScore W2012306172C86803240 @default.
- W2012306172 hasConceptScore W2012306172C95444343 @default.
- W2012306172 hasIssue "4" @default.
- W2012306172 hasLocation W20123061721 @default.
- W2012306172 hasLocation W20123061722 @default.
- W2012306172 hasOpenAccess W2012306172 @default.
- W2012306172 hasPrimaryLocation W20123061721 @default.
- W2012306172 hasRelatedWork W1872437643 @default.
- W2012306172 hasRelatedWork W2004944719 @default.
- W2012306172 hasRelatedWork W2047265391 @default.
- W2012306172 hasRelatedWork W2049126269 @default.
- W2012306172 hasRelatedWork W2080754801 @default.
- W2012306172 hasRelatedWork W2104244471 @default.
- W2012306172 hasRelatedWork W2115721083 @default.
- W2012306172 hasRelatedWork W2142205197 @default.
- W2012306172 hasRelatedWork W3195645878 @default.
- W2012306172 hasRelatedWork W4200167549 @default.
- W2012306172 hasVolume "11" @default.
- W2012306172 isParatext "false" @default.
- W2012306172 isRetracted "false" @default.
- W2012306172 magId "2012306172" @default.
- W2012306172 workType "article" @default.