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- W2012307222 abstract "Measurements of the acute toxicity of 2,6-di-tert-butyl-4-nitrophenol (dibutylnitrophenol; Bayer 28589) indicated that this compound has a low toxicity as evidenced by the following LD50 values in mg/kg when the compound was given intraperitoneally: female rats 260, male rats 270, male guinea pigs 580, female mice 850, and male mice 700. By the oral route the compound was about one-half as toxic as it was when given parenterally. The compound had a relatively high tendency to produce a cumulative toxic action as evidenced by mortality of animals given daily intraperitoneal doses equivalent to or in excess of one-tenth of the acute LD50 or levels exceeding 0.1% in the diet. Microscopic examination of the tissues of acutely poisoned animals showed degenerative changes in the heart, liver, spleen, kidney, and lung. The most pronounced changes consisted of patchy, waxy, degeneration of the heart, mild to moderate fatty changes in the liver, and lymphorrhexis, abortive mitosis, and other cellular changes in the spleen. The kidney exhibited zonal necrosis and degeneration of the tubular epithelium. These structural changes in the kidney were accompanied by functional changes consisting of a reduction in urineconcentrating ability and a rise in blood urea nitrogen." @default.
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- W2012307222 date "1961-11-01" @default.
- W2012307222 modified "2023-10-16" @default.
- W2012307222 title "Mammalian toxicity and histopathologic effects of 2,6-dibutyl-4-nitrophenol" @default.
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- W2012307222 doi "https://doi.org/10.1016/0041-008x(61)90035-7" @default.
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