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- W2012308354 abstract "Aims: To examine potential similarities in neural activation during the STROOP colour word test (SCWT) in patients with Bipolar Disorder (BD) and their unaffected first degree relatives of BD patients as an expression of genetic predisposition. Methods: 39 remitted BD patients were compared to 46 of their healthy relatives and to 42 controls. fMRI data were collected on a 1.5 T GE Signa MR system using a blocked periodic design and analysed in SPM5. Results: There was no statistically significant group difference in the behavioural performance. At the corrected cluster level threshold of p< 0.001 controls showed more activation than: a. BD patients in the caudate, the inferior (BA 47), middle and superior frontal gyri (BA 8, 6, 46), the parietal cortices (BA 7, 40), the precuneus and occipital cortices (BA 7, 19). b. Relatives in the caudate and cingulate cortex (BA 24, 31!). No other contrasts were significant. Conclusion: These findings suggest that changes in neural activation during response inhibition may reflect genetic predisposition to BD." @default.
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- W2012308354 date "2009-01-01" @default.
- W2012308354 modified "2023-09-24" @default.
- W2012308354 title "Neural Activation During the STROOP Task in Bipolar Disorder Patients and Their Unaffected Relatives" @default.
- W2012308354 doi "https://doi.org/10.1016/s0924-9338(09)70931-9" @default.
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