FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012308869> ?p ?o ?g. }

• W2012308869 endingPage "2114" @default.
• W2012308869 startingPage "2102" @default.
• W2012308869 abstract "Abstract: We have previously reported that high-density lipoprotein (HDL) exhibits antineuritogenic effects on chicken cerebral cells in culture. In the present study, we show the effects of HDLs, oxidized by UV irradiation or heating, on chicken cerebral neurons in culture. Both treatments produced several physical and chemical changes in the HDLs, i.e., formation of lipid peroxides, enlargement of HDL diameters, an increased exposure of the tryptophan groups of the apolipoprotein A-I to a more hydrophilic environment, formation of bityrosines, and cross-linking of apolipoprotein A-I. When these treatments were performed in the absence of EDTA, most of the modifications described above were more intense and HDLs formed a macroaggregate that displays a rosette-like structure. The aggregated HDLs produced neurodegeneration and death when added to both undifferentiated and differentiated cerebral neurons in culture. This process was accompanied by the disorganization of the cellular microtubular cytoskeleton and hyperphosphorylation of the microtubule-associated protein tau. Native HDL or HDLs treated in the presence of EDTA inhibited the neuritogenesis of undifferentiated neurons but did not show any significant effect on the differentiated neurons in culture. The effects on the cellular cytoskeleton and morphology of aggregated HDLs recall those of the fibrillar β-amyloid peptide. The present results suggest that aggregated HDLs could participate in neurodegeneration associated with oxidative stress in the CNS." @default.
• W2012308869 created "2016-06-24" @default.
• W2012308869 creator A5002764364 @default.
• W2012308869 creator A5026409216 @default.
• W2012308869 creator A5076550585 @default.
• W2012308869 creator A5078649753 @default.
• W2012308869 creator A5089123433 @default.
• W2012308869 date "2002-11-18" @default.
• W2012308869 modified "2023-10-06" @default.
• W2012308869 title "High-Density Lipoprotein Aggregated by Oxidation Induces Degeneration of Neuronal Cells" @default.
• W2012308869 cites W13663154 @default.
• W2012308869 cites W1486774324 @default.
• W2012308869 cites W1504706920 @default.
• W2012308869 cites W1521655014 @default.
• W2012308869 cites W1537453135 @default.
• W2012308869 cites W1555842933 @default.
• W2012308869 cites W1604658771 @default.
• W2012308869 cites W188370024 @default.
• W2012308869 cites W1963917943 @default.
• W2012308869 cites W1965496447 @default.
• W2012308869 cites W1968837461 @default.
• W2012308869 cites W1969420977 @default.
• W2012308869 cites W1970771562 @default.
• W2012308869 cites W1971022440 @default.
• W2012308869 cites W1972701314 @default.
• W2012308869 cites W1973682446 @default.
• W2012308869 cites W1979652057 @default.
• W2012308869 cites W1981570625 @default.
• W2012308869 cites W1981727187 @default.
• W2012308869 cites W1990427131 @default.
• W2012308869 cites W1992689843 @default.
• W2012308869 cites W1994030229 @default.
• W2012308869 cites W1996216953 @default.
• W2012308869 cites W1996917933 @default.
• W2012308869 cites W1997913988 @default.
• W2012308869 cites W2000849414 @default.
• W2012308869 cites W2002427949 @default.
• W2012308869 cites W2004955389 @default.
• W2012308869 cites W2007010231 @default.
• W2012308869 cites W2015786699 @default.
• W2012308869 cites W2017988471 @default.
• W2012308869 cites W2022793196 @default.
• W2012308869 cites W2024672368 @default.
• W2012308869 cites W2024935441 @default.
• W2012308869 cites W2028142995 @default.
• W2012308869 cites W2032722811 @default.
• W2012308869 cites W2032766742 @default.
• W2012308869 cites W2045441299 @default.
• W2012308869 cites W2045463471 @default.
• W2012308869 cites W2046880524 @default.
• W2012308869 cites W2057196062 @default.
• W2012308869 cites W2057842537 @default.
• W2012308869 cites W2059214757 @default.
• W2012308869 cites W2063670841 @default.
• W2012308869 cites W2074538483 @default.
• W2012308869 cites W2076013624 @default.
• W2012308869 cites W2076830729 @default.
• W2012308869 cites W2082336678 @default.
• W2012308869 cites W2083663079 @default.
• W2012308869 cites W2087969945 @default.
• W2012308869 cites W2088799696 @default.
• W2012308869 cites W2095281255 @default.
• W2012308869 cites W2106831400 @default.
• W2012308869 cites W2118206405 @default.
• W2012308869 cites W2118480498 @default.
• W2012308869 cites W2120402864 @default.
• W2012308869 cites W2122884624 @default.
• W2012308869 cites W2129995310 @default.
• W2012308869 cites W2177288739 @default.
• W2012308869 cites W2303325200 @default.
• W2012308869 cites W2341638556 @default.
• W2012308869 cites W2418657665 @default.
• W2012308869 cites W2461705289 @default.
• W2012308869 cites W2944810619 @default.
• W2012308869 cites W350446038 @default.
• W2012308869 doi "https://doi.org/10.1046/j.1471-4159.1997.69052102.x" @default.
• W2012308869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9349556" @default.
• W2012308869 hasPublicationYear "2002" @default.
• W2012308869 type Work @default.
• W2012308869 sameAs 2012308869 @default.
• W2012308869 citedByCount "25" @default.
• W2012308869 countsByYear W20123088692014 @default.
• W2012308869 countsByYear W20123088692015 @default.
• W2012308869 countsByYear W20123088692016 @default.
• W2012308869 countsByYear W20123088692018 @default.
• W2012308869 crossrefType "journal-article" @default.
• W2012308869 hasAuthorship W2012308869A5002764364 @default.
• W2012308869 hasAuthorship W2012308869A5026409216 @default.
• W2012308869 hasAuthorship W2012308869A5076550585 @default.
• W2012308869 hasAuthorship W2012308869A5078649753 @default.
• W2012308869 hasAuthorship W2012308869A5089123433 @default.
• W2012308869 hasConcept C126322002 @default.
• W2012308869 hasConcept C142669718 @default.
• W2012308869 hasConcept C1491633281 @default.
• W2012308869 hasConcept C185592680 @default.
• W2012308869 hasConcept C20418707 @default.
• W2012308869 hasConcept C2776151105 @default.
• W2012308869 hasConcept C2776925932 @default.

• next