Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012309111> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2012309111 abstract "The cancer/testis antigen (CT) family is defined by its specific expression pattern. In most cases CT antigens are expressed in normal human tissue only in germline cells and some tumors. Because of their restricted expression pattern CT antigens are regarded as potential targets for vaccine immunotherapy. Little is known about the functions of the various CT antigens. Some of these CT antigens (CT 7; MAGE A3/6) seem to be involved in the dysregulation of cell-cycle control and increased cell proliferation. The monoclonal antibody Ki-A10 detects a nuclear antigen with a unique distribution pattern in normal human tissues and tumors. The antigen is now characterized as cancer/testis antigen 45 (CT45).The accurate localisation of CT45 could provide details about its function. Therefore immunfluorescence stainings with subsequent confocal laser microscope analysis were performed to deliver precise data about the nuclear localisation of CT45. Different human tumor celllines (L428, HT1080, WS1-CLS, SW872) and 5-aza-2'-deoxycytidine treated human peripheral blood lymphocytes were stained with mab Ki-A10. All stainings showed an irregular and dotlike pattern, which is wellknown for nuclear speckles (interchromatin granule clusters). Nuclear speckles are dynamic structures known to harbour many proteins of the pre-mRNA splicing machinery. In addition CT45 shows a clear homology to a DEAD-Box protein (DDX26). DEAD-Box proteins are generally believed to be RNA helicases, which in turn are localised in nuclear speckles. Due to these results we believe that CT45 could be involved in pre-mRNA splicing." @default.
- W2012309111 created "2016-06-24" @default.
- W2012309111 creator A5012519428 @default.
- W2012309111 creator A5014049899 @default.
- W2012309111 creator A5016948656 @default.
- W2012309111 creator A5063241074 @default.
- W2012309111 date "2009-02-26" @default.
- W2012309111 modified "2023-09-26" @default.
- W2012309111 title "Cancer/testis antigen 45 is expressed in a nuclear speckles-like pattern in human tumor cell lines" @default.
- W2012309111 doi "https://doi.org/10.1186/1478-811x-7-s1-a31" @default.
- W2012309111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4291708" @default.
- W2012309111 hasPublicationYear "2009" @default.
- W2012309111 type Work @default.
- W2012309111 sameAs 2012309111 @default.
- W2012309111 citedByCount "0" @default.
- W2012309111 crossrefType "journal-article" @default.
- W2012309111 hasAuthorship W2012309111A5012519428 @default.
- W2012309111 hasAuthorship W2012309111A5014049899 @default.
- W2012309111 hasAuthorship W2012309111A5016948656 @default.
- W2012309111 hasAuthorship W2012309111A5063241074 @default.
- W2012309111 hasBestOaLocation W20123091111 @default.
- W2012309111 hasConcept C104317684 @default.
- W2012309111 hasConcept C105686024 @default.
- W2012309111 hasConcept C121608353 @default.
- W2012309111 hasConcept C147483822 @default.
- W2012309111 hasConcept C153911025 @default.
- W2012309111 hasConcept C190062978 @default.
- W2012309111 hasConcept C203014093 @default.
- W2012309111 hasConcept C2776662205 @default.
- W2012309111 hasConcept C2777701055 @default.
- W2012309111 hasConcept C2780114586 @default.
- W2012309111 hasConcept C502942594 @default.
- W2012309111 hasConcept C54355233 @default.
- W2012309111 hasConcept C54458228 @default.
- W2012309111 hasConcept C67705224 @default.
- W2012309111 hasConcept C83640560 @default.
- W2012309111 hasConcept C86803240 @default.
- W2012309111 hasConcept C95444343 @default.
- W2012309111 hasConceptScore W2012309111C104317684 @default.
- W2012309111 hasConceptScore W2012309111C105686024 @default.
- W2012309111 hasConceptScore W2012309111C121608353 @default.
- W2012309111 hasConceptScore W2012309111C147483822 @default.
- W2012309111 hasConceptScore W2012309111C153911025 @default.
- W2012309111 hasConceptScore W2012309111C190062978 @default.
- W2012309111 hasConceptScore W2012309111C203014093 @default.
- W2012309111 hasConceptScore W2012309111C2776662205 @default.
- W2012309111 hasConceptScore W2012309111C2777701055 @default.
- W2012309111 hasConceptScore W2012309111C2780114586 @default.
- W2012309111 hasConceptScore W2012309111C502942594 @default.
- W2012309111 hasConceptScore W2012309111C54355233 @default.
- W2012309111 hasConceptScore W2012309111C54458228 @default.
- W2012309111 hasConceptScore W2012309111C67705224 @default.
- W2012309111 hasConceptScore W2012309111C83640560 @default.
- W2012309111 hasConceptScore W2012309111C86803240 @default.
- W2012309111 hasConceptScore W2012309111C95444343 @default.
- W2012309111 hasLocation W20123091111 @default.
- W2012309111 hasLocation W20123091112 @default.
- W2012309111 hasLocation W20123091113 @default.
- W2012309111 hasLocation W20123091114 @default.
- W2012309111 hasOpenAccess W2012309111 @default.
- W2012309111 hasPrimaryLocation W20123091111 @default.
- W2012309111 hasRelatedWork W1637616723 @default.
- W2012309111 hasRelatedWork W1829170902 @default.
- W2012309111 hasRelatedWork W1845163208 @default.
- W2012309111 hasRelatedWork W1973925144 @default.
- W2012309111 hasRelatedWork W2006316604 @default.
- W2012309111 hasRelatedWork W2013010261 @default.
- W2012309111 hasRelatedWork W2014712763 @default.
- W2012309111 hasRelatedWork W2040144054 @default.
- W2012309111 hasRelatedWork W2048563301 @default.
- W2012309111 hasRelatedWork W2054583078 @default.
- W2012309111 hasRelatedWork W2082798065 @default.
- W2012309111 hasRelatedWork W2101937922 @default.
- W2012309111 hasRelatedWork W215023218 @default.
- W2012309111 hasRelatedWork W216441896 @default.
- W2012309111 hasRelatedWork W2217836684 @default.
- W2012309111 hasRelatedWork W2330793793 @default.
- W2012309111 hasRelatedWork W2994654970 @default.
- W2012309111 hasRelatedWork W2417939237 @default.
- W2012309111 hasRelatedWork W2575397670 @default.
- W2012309111 hasRelatedWork W3142280801 @default.
- W2012309111 isParatext "false" @default.
- W2012309111 isRetracted "false" @default.
- W2012309111 magId "2012309111" @default.
- W2012309111 workType "article" @default.