Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012310024> ?p ?o ?g. }
- W2012310024 endingPage "322" @default.
- W2012310024 startingPage "315" @default.
- W2012310024 abstract "Carbamazepine (CBZ), an antiepileptic with narrow therapeutic window, is a substrate of CYP 3A which metabolizes CBZ to carbamazepine-10,11-epoxide (CBZE), an active metabolite. This study investigated the acute and chronic effects of Polygonum cuspidatum (PC), a resveratrol‐rich nutraceutical, on the pharmacokinetics of CBZ in rats and the underlying mechanisms. Rats were orally administered CBZ (200 mg/kg) alone and coadministered with a single dose and the 7th dose of PC (2 g/kg) in a crossover design. The concentrations of CBZ and CBZE in serum and various tissues were determined by HPLC method. The results showed that PC significantly increased the AUC0-t of CBZ and CBZE, whereas the formation rate of CBZE was decreased. Tissue analysis showed that the concentrations of CBZ and CBZE in brain, liver and kidney were significantly increased by PC. Cell studies indicated that the efflux function of MRP 2 was inhibited by the serum metabolites of PC. In conclusion, PC markedly increased the systemic exposure and brain concentration of CBZ and CBZE through inhibiting the activities of CYP 3A and MRP 2." @default.
- W2012310024 created "2016-06-24" @default.
- W2012310024 creator A5056989253 @default.
- W2012310024 creator A5059454915 @default.
- W2012310024 creator A5073324646 @default.
- W2012310024 date "2012-09-01" @default.
- W2012310024 modified "2023-10-02" @default.
- W2012310024 title "A new herb–drug interaction of Polygonum cuspidatum, a resveratrol‐rich nutraceutical, with carbamazepine in rats" @default.
- W2012310024 cites W1550871940 @default.
- W2012310024 cites W1879832764 @default.
- W2012310024 cites W1956099131 @default.
- W2012310024 cites W1969109023 @default.
- W2012310024 cites W1975939285 @default.
- W2012310024 cites W1982405580 @default.
- W2012310024 cites W2012077091 @default.
- W2012310024 cites W2014297915 @default.
- W2012310024 cites W2019306848 @default.
- W2012310024 cites W2020040871 @default.
- W2012310024 cites W2022187559 @default.
- W2012310024 cites W2030087686 @default.
- W2012310024 cites W2031178488 @default.
- W2012310024 cites W2033493930 @default.
- W2012310024 cites W2054261703 @default.
- W2012310024 cites W2057802344 @default.
- W2012310024 cites W2060716969 @default.
- W2012310024 cites W2065239004 @default.
- W2012310024 cites W2068537129 @default.
- W2012310024 cites W2077796674 @default.
- W2012310024 cites W2079619305 @default.
- W2012310024 cites W2081967166 @default.
- W2012310024 cites W2082427007 @default.
- W2012310024 cites W2096219104 @default.
- W2012310024 cites W2112820588 @default.
- W2012310024 cites W2119331100 @default.
- W2012310024 cites W2123991024 @default.
- W2012310024 cites W2134353344 @default.
- W2012310024 cites W2136830554 @default.
- W2012310024 cites W2137790072 @default.
- W2012310024 cites W2143706492 @default.
- W2012310024 cites W2144618543 @default.
- W2012310024 cites W2148917087 @default.
- W2012310024 cites W2151508249 @default.
- W2012310024 cites W2170777657 @default.
- W2012310024 cites W2321102680 @default.
- W2012310024 cites W2409829112 @default.
- W2012310024 cites W4293247451 @default.
- W2012310024 cites W4376848378 @default.
- W2012310024 doi "https://doi.org/10.1016/j.taap.2012.07.003" @default.
- W2012310024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22813711" @default.
- W2012310024 hasPublicationYear "2012" @default.
- W2012310024 type Work @default.
- W2012310024 sameAs 2012310024 @default.
- W2012310024 citedByCount "36" @default.
- W2012310024 countsByYear W20123100242013 @default.
- W2012310024 countsByYear W20123100242014 @default.
- W2012310024 countsByYear W20123100242015 @default.
- W2012310024 countsByYear W20123100242016 @default.
- W2012310024 countsByYear W20123100242017 @default.
- W2012310024 countsByYear W20123100242018 @default.
- W2012310024 countsByYear W20123100242020 @default.
- W2012310024 countsByYear W20123100242021 @default.
- W2012310024 countsByYear W20123100242022 @default.
- W2012310024 countsByYear W20123100242023 @default.
- W2012310024 crossrefType "journal-article" @default.
- W2012310024 hasAuthorship W2012310024A5056989253 @default.
- W2012310024 hasAuthorship W2012310024A5059454915 @default.
- W2012310024 hasAuthorship W2012310024A5073324646 @default.
- W2012310024 hasConcept C112705442 @default.
- W2012310024 hasConcept C118552586 @default.
- W2012310024 hasConcept C149151106 @default.
- W2012310024 hasConcept C185592680 @default.
- W2012310024 hasConcept C2775858608 @default.
- W2012310024 hasConcept C2776816829 @default.
- W2012310024 hasConcept C2777477808 @default.
- W2012310024 hasConcept C2778186239 @default.
- W2012310024 hasConcept C2779253243 @default.
- W2012310024 hasConcept C55493867 @default.
- W2012310024 hasConcept C71924100 @default.
- W2012310024 hasConcept C98274493 @default.
- W2012310024 hasConceptScore W2012310024C112705442 @default.
- W2012310024 hasConceptScore W2012310024C118552586 @default.
- W2012310024 hasConceptScore W2012310024C149151106 @default.
- W2012310024 hasConceptScore W2012310024C185592680 @default.
- W2012310024 hasConceptScore W2012310024C2775858608 @default.
- W2012310024 hasConceptScore W2012310024C2776816829 @default.
- W2012310024 hasConceptScore W2012310024C2777477808 @default.
- W2012310024 hasConceptScore W2012310024C2778186239 @default.
- W2012310024 hasConceptScore W2012310024C2779253243 @default.
- W2012310024 hasConceptScore W2012310024C55493867 @default.
- W2012310024 hasConceptScore W2012310024C71924100 @default.
- W2012310024 hasConceptScore W2012310024C98274493 @default.
- W2012310024 hasIssue "3" @default.
- W2012310024 hasLocation W20123100241 @default.
- W2012310024 hasLocation W20123100242 @default.
- W2012310024 hasOpenAccess W2012310024 @default.
- W2012310024 hasPrimaryLocation W20123100241 @default.
- W2012310024 hasRelatedWork W1964759623 @default.
- W2012310024 hasRelatedWork W1998356222 @default.