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- W2012310860 abstract "The delay in initiation and continuation of DNA synthesis after treatments during G 1 and early S with cycloheximide (CHM, 5 μg/ml) or puromycin (PUR, 50 μg/ml), inhibitors of protein synthesis, has been studied in synchronous Chinese hamster ovary cells. Although protein synthesis is inhibited by more than 95% within 10 or 30 min after administering CHM or PUR, respectively, cells located in early S can synthesize DNA (incorporate 3HTdR) at a greatly reduced rate, and cells located in G1 within 55 min of S can initiate DNA synthesis during the 6-h treatment period. When the treatment is terminated, RNA and protein synthesis resume almost immediately, but the normal rate of DNA synthesis in cells located in early S phase is achieved only after RNA and protein synthesis have continued for about 3-h. This 3-h delay also is observed for the initiation of DNA synthesis in cells trapped in late G1 prior to a marker located 55 min before S. These results considered with our previous studies suggest that, in addition to the requirement for concomitant histone synthesis, there are labile factors, probably specific proteins, having a mean life of 2–3 h which are necessary (1) for the continuation of DNA synthesis at the normal rate; (2) for the progression of G1 cells into S if they are located more than 55 min prior to S." @default.
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- W2012310860 date "1972-12-01" @default.
- W2012310860 modified "2023-09-26" @default.
- W2012310860 title "Inhibition of DNA synthesis in synchronized Chinese hamster cells treated in G1 or early S phase with cycloheximide or puromycin" @default.
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- W2012310860 doi "https://doi.org/10.1016/0014-4827(72)90435-1" @default.
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