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- W2012310946 abstract "This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a promising pharmacokinetic profile and excellent selectivity over other closely related kinases." @default.
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- W2012310946 date "2008-03-01" @default.
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- W2012310946 title "Rapid assembly of diverse and potent allosteric Akt inhibitors" @default.
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- W2012310946 doi "https://doi.org/10.1016/j.bmcl.2007.10.023" @default.
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