FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012312043> ?p ?o ?g. }

• W2012312043 endingPage "142" @default.
• W2012312043 startingPage "135" @default.
• W2012312043 abstract "LINGO-1 is a transmembrane receptor expressed primarily in the central nervous system (CNS) and plays an important role in myelination. Recent studies have indicated that it is also involved in oligodendrocyte precursor cell (OPC) survival and differentiation; however, the downstream signaling pathway underlying OPC development is unknown. In our previous study, we found that LINGO-1 is associated with WNK1 in mediating Nogo-induced neurite extension inhibition by RhoA activation. In an effort to identify the role of LINGO-1-WNK1 in OPCs, we first confirmed that WNK1 is also expressed in OPCs and co-localized with LINGO-1, which suppresses WNK1 expression by RNA interference-attenuated Nogo66-induced inhibition of OPC differentiation. Furthermore, we mapped the WNK1 kinase domain using several fragmented peptides to identify the key region of interaction with LINGO-1. We found that a sequence corresponding to the D6 peptide is necessary for the interaction. Finally, we found that using the TAT-D6 peptide to introduce D6 peptide into primary cultured OPC inhibits the association between LINGO-1 and WNK1 and significantly attenuates Nogo66-induced inhibition of OPC differentiation. Taken together, our results show that WNK1, via a specific region on WNK1 kinase domain, interacts with LINGO-1, thus mediating Nogo66-inhibited OPC differentiation." @default.
• W2012312043 created "2016-06-24" @default.
• W2012312043 creator A5012494344 @default.
• W2012312043 creator A5025822039 @default.
• W2012312043 creator A5039919835 @default.
• W2012312043 creator A5043023301 @default.
• W2012312043 creator A5065410319 @default.
• W2012312043 creator A5066057809 @default.
• W2012312043 creator A5088774140 @default.
• W2012312043 date "2015-03-01" @default.
• W2012312043 modified "2023-10-15" @default.
• W2012312043 title "WNK1 is involved in Nogo66 inhibition of OPC differentiation" @default.
• W2012312043 cites W1971675257 @default.
• W2012312043 cites W1972782611 @default.
• W2012312043 cites W1975930394 @default.
• W2012312043 cites W1984891852 @default.
• W2012312043 cites W1989936163 @default.
• W2012312043 cites W2000071829 @default.
• W2012312043 cites W2003159334 @default.
• W2012312043 cites W2009955902 @default.
• W2012312043 cites W2023367024 @default.
• W2012312043 cites W2026159064 @default.
• W2012312043 cites W2027797460 @default.
• W2012312043 cites W2031747572 @default.
• W2012312043 cites W2032744361 @default.
• W2012312043 cites W2042852929 @default.
• W2012312043 cites W2047850628 @default.
• W2012312043 cites W2048159994 @default.
• W2012312043 cites W2049031671 @default.
• W2012312043 cites W2052960773 @default.
• W2012312043 cites W2056614538 @default.
• W2012312043 cites W2062326815 @default.
• W2012312043 cites W2074924223 @default.
• W2012312043 cites W2085879860 @default.
• W2012312043 cites W2094044389 @default.
• W2012312043 cites W2131619765 @default.
• W2012312043 cites W2132670847 @default.
• W2012312043 cites W2144540270 @default.
• W2012312043 cites W2149942972 @default.
• W2012312043 cites W2159727648 @default.
• W2012312043 cites W2159729185 @default.
• W2012312043 doi "https://doi.org/10.1016/j.mcn.2015.03.003" @default.
• W2012312043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25749374" @default.
• W2012312043 hasPublicationYear "2015" @default.
• W2012312043 type Work @default.
• W2012312043 sameAs 2012312043 @default.
• W2012312043 citedByCount "16" @default.
• W2012312043 countsByYear W20123120432016 @default.
• W2012312043 countsByYear W20123120432017 @default.
• W2012312043 countsByYear W20123120432018 @default.
• W2012312043 countsByYear W20123120432019 @default.
• W2012312043 countsByYear W20123120432020 @default.
• W2012312043 countsByYear W20123120432021 @default.
• W2012312043 countsByYear W20123120432023 @default.
• W2012312043 crossrefType "journal-article" @default.
• W2012312043 hasAuthorship W2012312043A5012494344 @default.
• W2012312043 hasAuthorship W2012312043A5025822039 @default.
• W2012312043 hasAuthorship W2012312043A5039919835 @default.
• W2012312043 hasAuthorship W2012312043A5043023301 @default.
• W2012312043 hasAuthorship W2012312043A5065410319 @default.
• W2012312043 hasAuthorship W2012312043A5066057809 @default.
• W2012312043 hasAuthorship W2012312043A5088774140 @default.
• W2012312043 hasConcept C104317684 @default.
• W2012312043 hasConcept C113246987 @default.
• W2012312043 hasConcept C148738053 @default.
• W2012312043 hasConcept C153911025 @default.
• W2012312043 hasConcept C166703698 @default.
• W2012312043 hasConcept C169760540 @default.
• W2012312043 hasConcept C170493617 @default.
• W2012312043 hasConcept C202751555 @default.
• W2012312043 hasConcept C24530287 @default.
• W2012312043 hasConcept C2776985911 @default.
• W2012312043 hasConcept C2777093181 @default.
• W2012312043 hasConcept C2778609137 @default.
• W2012312043 hasConcept C2779281246 @default.
• W2012312043 hasConcept C529278444 @default.
• W2012312043 hasConcept C54355233 @default.
• W2012312043 hasConcept C55493867 @default.
• W2012312043 hasConcept C62478195 @default.
• W2012312043 hasConcept C67705224 @default.
• W2012312043 hasConcept C86803240 @default.
• W2012312043 hasConcept C95444343 @default.
• W2012312043 hasConceptScore W2012312043C104317684 @default.
• W2012312043 hasConceptScore W2012312043C113246987 @default.
• W2012312043 hasConceptScore W2012312043C148738053 @default.
• W2012312043 hasConceptScore W2012312043C153911025 @default.
• W2012312043 hasConceptScore W2012312043C166703698 @default.
• W2012312043 hasConceptScore W2012312043C169760540 @default.
• W2012312043 hasConceptScore W2012312043C170493617 @default.
• W2012312043 hasConceptScore W2012312043C202751555 @default.
• W2012312043 hasConceptScore W2012312043C24530287 @default.
• W2012312043 hasConceptScore W2012312043C2776985911 @default.
• W2012312043 hasConceptScore W2012312043C2777093181 @default.
• W2012312043 hasConceptScore W2012312043C2778609137 @default.
• W2012312043 hasConceptScore W2012312043C2779281246 @default.
• W2012312043 hasConceptScore W2012312043C529278444 @default.
• W2012312043 hasConceptScore W2012312043C54355233 @default.
• W2012312043 hasConceptScore W2012312043C55493867 @default.

• next