Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012313276> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2012313276 endingPage "2850" @default.
- W2012313276 startingPage "2843" @default.
- W2012313276 abstract "p63 shares considerable sequence identity with p53, especially in its DNA-binding, activation and tetramerization domains. When the upstream promoter is used for p63 expression, three major transactivation p63 (TAp63) isoforms (α, β and γ) are produced. p63 is also expressed from an alternate promoter located in intron 3, producing three major ΔNp63 isoforms. Recent studies demonstrated that p63 has the potential to function as a tumor suppressor or an oncoprotein. To further address this, we generated cell lines that inducibly express each TAp63 isoform. We showed that TAp63 isoforms are capable of inducing p53-responsive genes, inhibiting cell proliferation and promoting apoptosis. Interestingly, we discovered that both the activation domain (residues 1–59) and the proline-rich domain (residues 67–127) are required for TAp63 transcriptional activity. Likewise, TAp63β(ΔPRD), deleted of residues 60–133, possessed a greatly attenuated ability to induce endogenous target genes and promote apoptosis, but retained the ability to inhibit cell proliferation when expressed in stable, inducible cell lines. TAp63β(ΔPRD) also functioned as a dominant negative to wild-type p63β in a dose-dependent manner. Furthermore, the loss of function seen with deletion of the proline-rich domain was not due to a DNA-binding defect, as TAp63β(ΔPRD) was found to strongly bind endogenous promoters using chromatin immunoprecipitation assay. Finally, mutational analysis revealed that a PXXP motif at residues 124–127 contributes to the transcriptional activity of TAp63. Altogether, our findings suggest that TAp63 transcriptional activity can be regulated by modification(s) of, or protein interactions with, the p63 proline-rich domain." @default.
- W2012313276 created "2016-06-24" @default.
- W2012313276 creator A5002191937 @default.
- W2012313276 creator A5055174519 @default.
- W2012313276 creator A5087625018 @default.
- W2012313276 date "2007-11-26" @default.
- W2012313276 modified "2023-10-12" @default.
- W2012313276 title "The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63" @default.
- W2012313276 cites W1482923899 @default.
- W2012313276 cites W1534987406 @default.
- W2012313276 cites W1954929088 @default.
- W2012313276 cites W1969485909 @default.
- W2012313276 cites W1992760686 @default.
- W2012313276 cites W2005013681 @default.
- W2012313276 cites W2013126678 @default.
- W2012313276 cites W2014938226 @default.
- W2012313276 cites W2018578533 @default.
- W2012313276 cites W2023206012 @default.
- W2012313276 cites W2037509005 @default.
- W2012313276 cites W2042532593 @default.
- W2012313276 cites W2044316781 @default.
- W2012313276 cites W2063814011 @default.
- W2012313276 cites W2067170822 @default.
- W2012313276 cites W2080704341 @default.
- W2012313276 cites W2104660225 @default.
- W2012313276 cites W2126807376 @default.
- W2012313276 cites W2129905922 @default.
- W2012313276 cites W2141136258 @default.
- W2012313276 cites W2153314392 @default.
- W2012313276 cites W2167669999 @default.
- W2012313276 cites W2324799005 @default.
- W2012313276 doi "https://doi.org/10.1038/sj.onc.1210948" @default.
- W2012313276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2662334" @default.
- W2012313276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18037962" @default.
- W2012313276 hasPublicationYear "2007" @default.
- W2012313276 type Work @default.
- W2012313276 sameAs 2012313276 @default.
- W2012313276 citedByCount "26" @default.
- W2012313276 countsByYear W20123132762012 @default.
- W2012313276 countsByYear W20123132762013 @default.
- W2012313276 countsByYear W20123132762014 @default.
- W2012313276 countsByYear W20123132762016 @default.
- W2012313276 countsByYear W20123132762017 @default.
- W2012313276 countsByYear W20123132762019 @default.
- W2012313276 countsByYear W20123132762020 @default.
- W2012313276 countsByYear W20123132762021 @default.
- W2012313276 countsByYear W20123132762023 @default.
- W2012313276 crossrefType "journal-article" @default.
- W2012313276 hasAuthorship W2012313276A5002191937 @default.
- W2012313276 hasAuthorship W2012313276A5055174519 @default.
- W2012313276 hasAuthorship W2012313276A5087625018 @default.
- W2012313276 hasBestOaLocation W20123132761 @default.
- W2012313276 hasConcept C101762097 @default.
- W2012313276 hasConcept C104317684 @default.
- W2012313276 hasConcept C1292079 @default.
- W2012313276 hasConcept C134320426 @default.
- W2012313276 hasConcept C150194340 @default.
- W2012313276 hasConcept C153911025 @default.
- W2012313276 hasConcept C33987129 @default.
- W2012313276 hasConcept C53345823 @default.
- W2012313276 hasConcept C55493867 @default.
- W2012313276 hasConcept C86339819 @default.
- W2012313276 hasConcept C86803240 @default.
- W2012313276 hasConcept C95444343 @default.
- W2012313276 hasConceptScore W2012313276C101762097 @default.
- W2012313276 hasConceptScore W2012313276C104317684 @default.
- W2012313276 hasConceptScore W2012313276C1292079 @default.
- W2012313276 hasConceptScore W2012313276C134320426 @default.
- W2012313276 hasConceptScore W2012313276C150194340 @default.
- W2012313276 hasConceptScore W2012313276C153911025 @default.
- W2012313276 hasConceptScore W2012313276C33987129 @default.
- W2012313276 hasConceptScore W2012313276C53345823 @default.
- W2012313276 hasConceptScore W2012313276C55493867 @default.
- W2012313276 hasConceptScore W2012313276C86339819 @default.
- W2012313276 hasConceptScore W2012313276C86803240 @default.
- W2012313276 hasConceptScore W2012313276C95444343 @default.
- W2012313276 hasIssue "20" @default.
- W2012313276 hasLocation W20123132761 @default.
- W2012313276 hasLocation W20123132762 @default.
- W2012313276 hasLocation W20123132763 @default.
- W2012313276 hasLocation W20123132764 @default.
- W2012313276 hasOpenAccess W2012313276 @default.
- W2012313276 hasPrimaryLocation W20123132761 @default.
- W2012313276 hasRelatedWork W1977174457 @default.
- W2012313276 hasRelatedWork W1979576412 @default.
- W2012313276 hasRelatedWork W2035906232 @default.
- W2012313276 hasRelatedWork W2076660617 @default.
- W2012313276 hasRelatedWork W2094831461 @default.
- W2012313276 hasRelatedWork W2110032403 @default.
- W2012313276 hasRelatedWork W2138786316 @default.
- W2012313276 hasRelatedWork W2234831416 @default.
- W2012313276 hasRelatedWork W3004638618 @default.
- W2012313276 hasRelatedWork W3115309223 @default.
- W2012313276 hasVolume "27" @default.
- W2012313276 isParatext "false" @default.
- W2012313276 isRetracted "false" @default.
- W2012313276 magId "2012313276" @default.
- W2012313276 workType "article" @default.