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• W2012313281 abstract "Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers. On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg." @default.
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• W2012313281 date "1981-04-01" @default.
• W2012313281 modified "2023-09-28" @default.
• W2012313281 title "Infusion of Vasoactive Intestinal Polypeptide in Man: Pharmacokinetics and Effect on Gastric Acid Secretion" @default.
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• W2012313281 doi "https://doi.org/10.3109/00365528109181992" @default.
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