Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012313386> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2012313386 endingPage "6331" @default.
- W2012313386 startingPage "6329" @default.
- W2012313386 abstract "Abstract The syntheses of β-amino acids 1 and 2 are presented by means of an alternative route to the asymmetric Michael-addition route reported in the preceding article. These two compounds, which bind to the α2δ subunit of calcium channels and have important medical applications, have been prepared on multi-kilogram scale in our pilot plant through a new approach that introduces the chirality at the β-carbon via asymmetric hydrogenation of an enamide precursor. Two Rh-based catalysts, (R)-mTCFP-Rh(COD)BF4 and (R)-binapine-Rh(COD)BF4, were found to be superior in this transformation and gave very high diastereoselectivities. The process development for catalyst selection is described." @default.
- W2012313386 created "2016-06-24" @default.
- W2012313386 creator A5005544652 @default.
- W2012313386 creator A5013338505 @default.
- W2012313386 creator A5039646549 @default.
- W2012313386 creator A5049167923 @default.
- W2012313386 creator A5073634724 @default.
- W2012313386 creator A5079976559 @default.
- W2012313386 creator A5081769790 @default.
- W2012313386 creator A5083657878 @default.
- W2012313386 date "2009-11-01" @default.
- W2012313386 modified "2023-09-23" @default.
- W2012313386 title "Diastereoselective, large scale synthesis of β-amino acids via asymmetric enamide hydrogenation as α2δ ligands for the treatment of generalized anxiety disorder and insomnia" @default.
- W2012313386 cites W1965704764 @default.
- W2012313386 cites W1983777096 @default.
- W2012313386 cites W1994891731 @default.
- W2012313386 cites W2058082212 @default.
- W2012313386 cites W2061277507 @default.
- W2012313386 cites W2076552560 @default.
- W2012313386 cites W2079425663 @default.
- W2012313386 cites W2080353426 @default.
- W2012313386 cites W2105787857 @default.
- W2012313386 cites W2134557432 @default.
- W2012313386 cites W2138889171 @default.
- W2012313386 cites W2143882204 @default.
- W2012313386 cites W2150377190 @default.
- W2012313386 cites W2160139718 @default.
- W2012313386 cites W2949576535 @default.
- W2012313386 cites W2952713374 @default.
- W2012313386 cites W4293587000 @default.
- W2012313386 doi "https://doi.org/10.1016/j.tetlet.2009.08.111" @default.
- W2012313386 hasPublicationYear "2009" @default.
- W2012313386 type Work @default.
- W2012313386 sameAs 2012313386 @default.
- W2012313386 citedByCount "13" @default.
- W2012313386 countsByYear W20123133862012 @default.
- W2012313386 countsByYear W20123133862013 @default.
- W2012313386 countsByYear W20123133862014 @default.
- W2012313386 countsByYear W20123133862018 @default.
- W2012313386 countsByYear W20123133862019 @default.
- W2012313386 crossrefType "journal-article" @default.
- W2012313386 hasAuthorship W2012313386A5005544652 @default.
- W2012313386 hasAuthorship W2012313386A5013338505 @default.
- W2012313386 hasAuthorship W2012313386A5039646549 @default.
- W2012313386 hasAuthorship W2012313386A5049167923 @default.
- W2012313386 hasAuthorship W2012313386A5073634724 @default.
- W2012313386 hasAuthorship W2012313386A5079976559 @default.
- W2012313386 hasAuthorship W2012313386A5081769790 @default.
- W2012313386 hasAuthorship W2012313386A5083657878 @default.
- W2012313386 hasConcept C118552586 @default.
- W2012313386 hasConcept C146686406 @default.
- W2012313386 hasConcept C15744967 @default.
- W2012313386 hasConcept C161790260 @default.
- W2012313386 hasConcept C178790620 @default.
- W2012313386 hasConcept C185592680 @default.
- W2012313386 hasConcept C197356162 @default.
- W2012313386 hasConcept C21951064 @default.
- W2012313386 hasConcept C2779911313 @default.
- W2012313386 hasConcept C2781210498 @default.
- W2012313386 hasConcept C515207424 @default.
- W2012313386 hasConcept C55493867 @default.
- W2012313386 hasConcept C558461103 @default.
- W2012313386 hasConceptScore W2012313386C118552586 @default.
- W2012313386 hasConceptScore W2012313386C146686406 @default.
- W2012313386 hasConceptScore W2012313386C15744967 @default.
- W2012313386 hasConceptScore W2012313386C161790260 @default.
- W2012313386 hasConceptScore W2012313386C178790620 @default.
- W2012313386 hasConceptScore W2012313386C185592680 @default.
- W2012313386 hasConceptScore W2012313386C197356162 @default.
- W2012313386 hasConceptScore W2012313386C21951064 @default.
- W2012313386 hasConceptScore W2012313386C2779911313 @default.
- W2012313386 hasConceptScore W2012313386C2781210498 @default.
- W2012313386 hasConceptScore W2012313386C515207424 @default.
- W2012313386 hasConceptScore W2012313386C55493867 @default.
- W2012313386 hasConceptScore W2012313386C558461103 @default.
- W2012313386 hasIssue "46" @default.
- W2012313386 hasLocation W20123133861 @default.
- W2012313386 hasOpenAccess W2012313386 @default.
- W2012313386 hasPrimaryLocation W20123133861 @default.
- W2012313386 hasRelatedWork W115484261 @default.
- W2012313386 hasRelatedWork W2001949934 @default.
- W2012313386 hasRelatedWork W2021182248 @default.
- W2012313386 hasRelatedWork W2038296361 @default.
- W2012313386 hasRelatedWork W2069890553 @default.
- W2012313386 hasRelatedWork W2495502429 @default.
- W2012313386 hasRelatedWork W2763305681 @default.
- W2012313386 hasRelatedWork W3002918314 @default.
- W2012313386 hasRelatedWork W4206154152 @default.
- W2012313386 hasRelatedWork W4378610834 @default.
- W2012313386 hasVolume "50" @default.
- W2012313386 isParatext "false" @default.
- W2012313386 isRetracted "false" @default.
- W2012313386 magId "2012313386" @default.
- W2012313386 workType "article" @default.