FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012313387> ?p ?o ?g. }

• W2012313387 endingPage "166" @default.
• W2012313387 startingPage "163" @default.
• W2012313387 abstract "In subacute cutaneous lupus eryhematosus (SCLE) the cutaneous antigens constitute the main source of Ro and La autoantigens. The aim of this investigation was to demonstrate if UV light increases the availability of Ro autoantigen in the skin, also the blocking effect of Ac-DEVD-CMK a caspase inhibitor was assessed. For this purpose newborn Balb/c mice were UVB irradiated (5–30 mJ/cm 2 ) equivalent to a moderate to severe sunburn. Animals were injected with monoclonal anti-Ro antibodies from SCLE patients. Apoptosis was also induced by anti-Fas antibody injection. Skin samples were examined by direct immunofluoresence, by TUNEL, and the expression of caspase 3 by RT-PCR. Major findings of present studies were: 1. UVB irradiation and anti-Fas induced apoptosis of keratinocytes. 2. Apoptosis redistribute the Ro antigen on cell surface and is better triggered by Ro antibody. 3. The caspase 3 inhibitor Ac-DEVD-CMK decreases the availability of Ro autoantigen in epidermis and prevents deposition of anti-Ro. In conclusion, the caspase pathway would be blocked to avoid anti-Ro deposition along skin; this finding would be a prospect in the treatment of SCLE patients." @default.
• W2012313387 created "2016-06-24" @default.
• W2012313387 creator A5009893289 @default.
• W2012313387 creator A5015183826 @default.
• W2012313387 creator A5056058314 @default.
• W2012313387 creator A5072851136 @default.
• W2012313387 creator A5079638851 @default.
• W2012313387 creator A5081962491 @default.
• W2012313387 creator A5089724051 @default.
• W2012313387 date "2006-01-01" @default.
• W2012313387 modified "2023-10-18" @default.
• W2012313387 title "Apoptosis and Redistribution of the Ro Autoantigen in Balb/c Mouse Like in Subacute Cutaneous Lupus Erythematosus" @default.
• W2012313387 cites W2109965462 @default.
• W2012313387 doi "https://doi.org/10.1080/17402520600876796" @default.
• W2012313387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2270769" @default.
• W2012313387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17162359" @default.
• W2012313387 hasPublicationYear "2006" @default.
• W2012313387 type Work @default.
• W2012313387 sameAs 2012313387 @default.
• W2012313387 citedByCount "19" @default.
• W2012313387 countsByYear W20123133872013 @default.
• W2012313387 countsByYear W20123133872014 @default.
• W2012313387 countsByYear W20123133872015 @default.
• W2012313387 countsByYear W20123133872018 @default.
• W2012313387 countsByYear W20123133872019 @default.
• W2012313387 countsByYear W20123133872020 @default.
• W2012313387 countsByYear W20123133872021 @default.
• W2012313387 countsByYear W20123133872023 @default.
• W2012313387 crossrefType "journal-article" @default.
• W2012313387 hasAuthorship W2012313387A5009893289 @default.
• W2012313387 hasAuthorship W2012313387A5015183826 @default.
• W2012313387 hasAuthorship W2012313387A5056058314 @default.
• W2012313387 hasAuthorship W2012313387A5072851136 @default.
• W2012313387 hasAuthorship W2012313387A5079638851 @default.
• W2012313387 hasAuthorship W2012313387A5081962491 @default.
• W2012313387 hasAuthorship W2012313387A5089724051 @default.
• W2012313387 hasBestOaLocation W20123133871 @default.
• W2012313387 hasConcept C147483822 @default.
• W2012313387 hasConcept C153911025 @default.
• W2012313387 hasConcept C159654299 @default.
• W2012313387 hasConcept C16005928 @default.
• W2012313387 hasConcept C185592680 @default.
• W2012313387 hasConcept C190283241 @default.
• W2012313387 hasConcept C196795494 @default.
• W2012313387 hasConcept C203014093 @default.
• W2012313387 hasConcept C204232928 @default.
• W2012313387 hasConcept C2776670291 @default.
• W2012313387 hasConcept C2777524492 @default.
• W2012313387 hasConcept C2777761306 @default.
• W2012313387 hasConcept C2779075594 @default.
• W2012313387 hasConcept C31573885 @default.
• W2012313387 hasConcept C542903549 @default.
• W2012313387 hasConcept C55493867 @default.
• W2012313387 hasConcept C56483683 @default.
• W2012313387 hasConcept C71924100 @default.
• W2012313387 hasConcept C86803240 @default.
• W2012313387 hasConcept C98424977 @default.
• W2012313387 hasConceptScore W2012313387C147483822 @default.
• W2012313387 hasConceptScore W2012313387C153911025 @default.
• W2012313387 hasConceptScore W2012313387C159654299 @default.
• W2012313387 hasConceptScore W2012313387C16005928 @default.
• W2012313387 hasConceptScore W2012313387C185592680 @default.
• W2012313387 hasConceptScore W2012313387C190283241 @default.
• W2012313387 hasConceptScore W2012313387C196795494 @default.
• W2012313387 hasConceptScore W2012313387C203014093 @default.
• W2012313387 hasConceptScore W2012313387C204232928 @default.
• W2012313387 hasConceptScore W2012313387C2776670291 @default.
• W2012313387 hasConceptScore W2012313387C2777524492 @default.
• W2012313387 hasConceptScore W2012313387C2777761306 @default.
• W2012313387 hasConceptScore W2012313387C2779075594 @default.
• W2012313387 hasConceptScore W2012313387C31573885 @default.
• W2012313387 hasConceptScore W2012313387C542903549 @default.
• W2012313387 hasConceptScore W2012313387C55493867 @default.
• W2012313387 hasConceptScore W2012313387C56483683 @default.
• W2012313387 hasConceptScore W2012313387C71924100 @default.
• W2012313387 hasConceptScore W2012313387C86803240 @default.
• W2012313387 hasConceptScore W2012313387C98424977 @default.
• W2012313387 hasFunder F4320321739 @default.
• W2012313387 hasIssue "2-4" @default.
• W2012313387 hasLocation W20123133871 @default.
• W2012313387 hasLocation W20123133872 @default.
• W2012313387 hasLocation W20123133873 @default.
• W2012313387 hasLocation W20123133874 @default.
• W2012313387 hasOpenAccess W2012313387 @default.
• W2012313387 hasPrimaryLocation W20123133871 @default.
• W2012313387 hasRelatedWork W1943797027 @default.
• W2012313387 hasRelatedWork W1969433283 @default.
• W2012313387 hasRelatedWork W1997716688 @default.
• W2012313387 hasRelatedWork W2029145496 @default.
• W2012313387 hasRelatedWork W2037509311 @default.
• W2012313387 hasRelatedWork W2038126255 @default.
• W2012313387 hasRelatedWork W2064089409 @default.
• W2012313387 hasRelatedWork W2068190618 @default.
• W2012313387 hasRelatedWork W2368460920 @default.
• W2012313387 hasRelatedWork W2380360044 @default.
• W2012313387 hasVolume "13" @default.
• W2012313387 isParatext "false" @default.
• W2012313387 isRetracted "false" @default.

• next