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- W2012316620 abstract "Prepulse inhibition (PPI) is a normal reduction in the startle response produced when a brief, low intensity stimulus is presented prior to a startle-evoking stimulus. PPI is often disrupted in humans diagnosed with schizophrenia. As similar stimuli elicit PPI in rodents and humans, interventions in rodents that disrupt PPI may reveal aspects of neuronal dysfunction relevant to schizophrenia. Stimulation of the ventral hippocampus (vHip) with NMDA significantly increases dopamine (DA) efflux in the nucleus accumbens (NAc) and disrupts PPI, whereas NMDA infusion into the dorsal hippocampus (dHip) fails to alter PPI. Our previous research shows that brief periods of 20 Hz electrical vHip stimulation also significantly increase NAc DA efflux. The present experiments assessed the effects of stimulating the vHip or dHip on PPI and NAc DA efflux. As predicted, 20 Hz stimulation (10 s, 300 microA) of the vHip, but not the dHip, reversibly disrupted PPI. In contrast, 2 Hz stimulation (100 s, 300 microA) of the vHip failed to affect PPI. Microdialysis experiments revealed that 20 Hz stimulation of the vHip increased NAc DA efflux only in the hemisphere ipsilateral to the stimulating electrode, whereas 20 Hz stimulation of the dHip failed to affect NAc DA efflux. These data demonstrate the regional specificity and frequency-dependent effects of hippocampal activity on PPI. Additionally, it is intriguing that both chemical and electrical stimulation of the vHip disrupt PPI and increase NAc DA efflux, however, the relevance of these changes in NAc DA efflux to the disruption of PPI remains to be determined." @default.
- W2012316620 created "2016-06-24" @default.
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- W2012316620 date "2004-07-01" @default.
- W2012316620 modified "2023-09-26" @default.
- W2012316620 title "Electrical stimulation of the hippocampus disrupts prepulse inhibition in rats: frequency- and site-dependent effects" @default.
- W2012316620 cites W116130616 @default.
- W2012316620 cites W1523611932 @default.
- W2012316620 cites W1558854723 @default.
- W2012316620 cites W1964240411 @default.
- W2012316620 cites W1967735036 @default.
- W2012316620 cites W1968138618 @default.
- W2012316620 cites W1969273085 @default.
- W2012316620 cites W1969957609 @default.
- W2012316620 cites W1974820883 @default.
- W2012316620 cites W1978196348 @default.
- W2012316620 cites W1980077228 @default.
- W2012316620 cites W1982135114 @default.
- W2012316620 cites W1983742440 @default.
- W2012316620 cites W1984305433 @default.
- W2012316620 cites W1985310141 @default.
- W2012316620 cites W1992522216 @default.
- W2012316620 cites W1993639998 @default.
- W2012316620 cites W1993706485 @default.
- W2012316620 cites W1996717195 @default.
- W2012316620 cites W1998141074 @default.
- W2012316620 cites W2004729128 @default.
- W2012316620 cites W2005756201 @default.
- W2012316620 cites W2008873264 @default.
- W2012316620 cites W2012105955 @default.
- W2012316620 cites W2013622904 @default.
- W2012316620 cites W2015531992 @default.
- W2012316620 cites W2016351053 @default.
- W2012316620 cites W2020549903 @default.
- W2012316620 cites W2021176333 @default.
- W2012316620 cites W2031709582 @default.
- W2012316620 cites W2036812929 @default.
- W2012316620 cites W2040690461 @default.
- W2012316620 cites W2041153769 @default.
- W2012316620 cites W2042676846 @default.
- W2012316620 cites W2044741978 @default.
- W2012316620 cites W2048024033 @default.
- W2012316620 cites W2049783116 @default.
- W2012316620 cites W2051962625 @default.
- W2012316620 cites W2052578687 @default.
- W2012316620 cites W2053232417 @default.
- W2012316620 cites W2053479675 @default.
- W2012316620 cites W2053740331 @default.
- W2012316620 cites W2057135100 @default.
- W2012316620 cites W2060137544 @default.
- W2012316620 cites W2060441063 @default.
- W2012316620 cites W2060884332 @default.
- W2012316620 cites W2063513639 @default.
- W2012316620 cites W2065671104 @default.
- W2012316620 cites W2070672269 @default.
- W2012316620 cites W2071426323 @default.
- W2012316620 cites W2072175866 @default.
- W2012316620 cites W2081224446 @default.
- W2012316620 cites W2083291818 @default.
- W2012316620 cites W2084989539 @default.
- W2012316620 cites W2088366298 @default.
- W2012316620 cites W2090920104 @default.
- W2012316620 cites W2090979638 @default.
- W2012316620 cites W2092046315 @default.
- W2012316620 cites W2092139956 @default.
- W2012316620 cites W2095836476 @default.
- W2012316620 cites W2124796879 @default.
- W2012316620 cites W2131795377 @default.
- W2012316620 cites W2135731923 @default.
- W2012316620 cites W2137983860 @default.
- W2012316620 cites W2139358036 @default.
- W2012316620 cites W2143100380 @default.
- W2012316620 cites W2145345810 @default.
- W2012316620 cites W2150760506 @default.
- W2012316620 cites W2156035025 @default.
- W2012316620 cites W2159648246 @default.
- W2012316620 cites W2171148473 @default.
- W2012316620 cites W2284323937 @default.
- W2012316620 cites W4248009138 @default.
- W2012316620 cites W4250653224 @default.
- W2012316620 cites W4302309364 @default.
- W2012316620 cites W1542604039 @default.
- W2012316620 doi "https://doi.org/10.1016/j.bbr.2003.10.001" @default.
- W2012316620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15196786" @default.
- W2012316620 hasPublicationYear "2004" @default.
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