FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012317247> ?p ?o ?g. }

• W2012317247 endingPage "44" @default.
• W2012317247 startingPage "38" @default.
• W2012317247 abstract "In some pathological conditions such as hypertension, there is an impairment in the autonomic control of blood pressure resulting in changes in baroreflex sensitivity. In the present study we tested the hypothesis that acute superoxide scavenging would restore the reduced baroreflex sensitivity in renovascular hypertension. Male Wistar rats underwent 2-Kidney-1-Clip (2K1C) or sham surgery and were maintained untouched for six weeks to develop hypertension. After six weeks, animals from the 2K1C group were hypertensive when compared to the sham group (165±9 vs. 108±7 mmHg, P<0.05). As a proof of principle for the hypertension model adopted, animals from the 2K1C group presented increased non-clipped kidney and cardiac mass index and reduced clipped kidney mass index. Regarding baroreflex, 2K1C rats presented diminished baroreflex sensitivity when compared to the sham group (2K1C+saline: −1.61±0.15 vs. sham+saline: −2.79±0.24 bpm mm Hg−1, p<0.05). Moreover, acute administration of Vitamin C (150 mg/Kg, i.v.) restored baroreflex sensitivity in 2K1C rats (2K1C+Vit C: −3.08±0.37 vs. 2K1C+saline: −1.61±0.15 bpm mm Hg−1, p<0.05). Furthermore, administration of apocynin (30 μg/Kg, i.v.), a NADPH oxidase inhibitor, also improved baroreflex sensitivity in the 2K1C group (2K1C+apocynin: −2.81±0.24 vs. 2K1C+saline: −1.61±0.15 bpm mm Hg−1, p<0.05). In addition, autonomic blockade with either methylatropine or propranolol reduced the changes in heart rate to the same extent in all groups suggesting that improved baroreflex sensitivity by antioxidants were mediated by improvement in autonomic function. Taken together, these data suggest that NADPH oxidase-derived reactive oxygen species are involved in the blunted baroreflex sensitivity in renovascular hypertension and that acute scavenging of superoxide restores baroreflex sensitivity." @default.
• W2012317247 created "2016-06-24" @default.
• W2012317247 creator A5039582274 @default.
• W2012317247 creator A5052718854 @default.
• W2012317247 creator A5057743293 @default.
• W2012317247 creator A5069780924 @default.
• W2012317247 creator A5072555714 @default.
• W2012317247 creator A5081344104 @default.
• W2012317247 date "2011-01-01" @default.
• W2012317247 modified "2023-10-17" @default.
• W2012317247 title "Acute superoxide scavenging restores depressed baroreflex sensitivity in renovascular hypertensive rats" @default.
• W2012317247 cites W1963611929 @default.
• W2012317247 cites W1966409424 @default.
• W2012317247 cites W1976555160 @default.
• W2012317247 cites W1981921279 @default.
• W2012317247 cites W1987729839 @default.
• W2012317247 cites W1994394104 @default.
• W2012317247 cites W1998031658 @default.
• W2012317247 cites W1998318767 @default.
• W2012317247 cites W2000756775 @default.
• W2012317247 cites W2001683673 @default.
• W2012317247 cites W2009970032 @default.
• W2012317247 cites W2014928325 @default.
• W2012317247 cites W2025916148 @default.
• W2012317247 cites W2034914370 @default.
• W2012317247 cites W2035446021 @default.
• W2012317247 cites W2036261470 @default.
• W2012317247 cites W2036674009 @default.
• W2012317247 cites W2063561249 @default.
• W2012317247 cites W2066811986 @default.
• W2012317247 cites W2071506405 @default.
• W2012317247 cites W2072197446 @default.
• W2012317247 cites W2075801313 @default.
• W2012317247 cites W2077538054 @default.
• W2012317247 cites W2082987567 @default.
• W2012317247 cites W2087728000 @default.
• W2012317247 cites W2097914135 @default.
• W2012317247 cites W2098934328 @default.
• W2012317247 cites W2104194332 @default.
• W2012317247 cites W2105233979 @default.
• W2012317247 cites W2110182057 @default.
• W2012317247 cites W2118287470 @default.
• W2012317247 cites W2119523842 @default.
• W2012317247 cites W2120334229 @default.
• W2012317247 cites W2126085531 @default.
• W2012317247 cites W2128791637 @default.
• W2012317247 cites W2133791947 @default.
• W2012317247 cites W2155882712 @default.
• W2012317247 cites W2169404376 @default.
• W2012317247 cites W2210811561 @default.
• W2012317247 cites W2323411228 @default.
• W2012317247 cites W4247794967 @default.
• W2012317247 doi "https://doi.org/10.1016/j.autneu.2010.07.025" @default.
• W2012317247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20719579" @default.
• W2012317247 hasPublicationYear "2011" @default.
• W2012317247 type Work @default.
• W2012317247 sameAs 2012317247 @default.
• W2012317247 citedByCount "43" @default.
• W2012317247 countsByYear W20123172472012 @default.
• W2012317247 countsByYear W20123172472013 @default.
• W2012317247 countsByYear W20123172472014 @default.
• W2012317247 countsByYear W20123172472015 @default.
• W2012317247 countsByYear W20123172472016 @default.
• W2012317247 countsByYear W20123172472017 @default.
• W2012317247 countsByYear W20123172472018 @default.
• W2012317247 countsByYear W20123172472019 @default.
• W2012317247 countsByYear W20123172472021 @default.
• W2012317247 countsByYear W20123172472022 @default.
• W2012317247 crossrefType "journal-article" @default.
• W2012317247 hasAuthorship W2012317247A5039582274 @default.
• W2012317247 hasAuthorship W2012317247A5052718854 @default.
• W2012317247 hasAuthorship W2012317247A5057743293 @default.
• W2012317247 hasAuthorship W2012317247A5069780924 @default.
• W2012317247 hasAuthorship W2012317247A5072555714 @default.
• W2012317247 hasAuthorship W2012317247A5081344104 @default.
• W2012317247 hasBestOaLocation W20123172471 @default.
• W2012317247 hasConcept C126322002 @default.
• W2012317247 hasConcept C134018914 @default.
• W2012317247 hasConcept C191237925 @default.
• W2012317247 hasConcept C2776151105 @default.
• W2012317247 hasConcept C2777209548 @default.
• W2012317247 hasConcept C2777397205 @default.
• W2012317247 hasConcept C2777953023 @default.
• W2012317247 hasConcept C2779719074 @default.
• W2012317247 hasConcept C2781243531 @default.
• W2012317247 hasConcept C42219234 @default.
• W2012317247 hasConcept C71924100 @default.
• W2012317247 hasConcept C84393581 @default.
• W2012317247 hasConceptScore W2012317247C126322002 @default.
• W2012317247 hasConceptScore W2012317247C134018914 @default.
• W2012317247 hasConceptScore W2012317247C191237925 @default.
• W2012317247 hasConceptScore W2012317247C2776151105 @default.
• W2012317247 hasConceptScore W2012317247C2777209548 @default.
• W2012317247 hasConceptScore W2012317247C2777397205 @default.
• W2012317247 hasConceptScore W2012317247C2777953023 @default.
• W2012317247 hasConceptScore W2012317247C2779719074 @default.
• W2012317247 hasConceptScore W2012317247C2781243531 @default.
• W2012317247 hasConceptScore W2012317247C42219234 @default.

• next