FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012320144> ?p ?o ?g. }

• W2012320144 endingPage "51" @default.
• W2012320144 startingPage "46" @default.
• W2012320144 abstract "Objective and Design Pain and peripheral neuropathy are frequent complications of end-stage renal disease (ESRD). Because drug treatment is associated with numerous side effects and is largely ineffective in many maintenance hemodialysis (MHD) patients, nonpharmacologic strategies such as electrotherapy are a potential recourse. Among various forms of electrostimulation, high-tone external muscle stimulation (HTEMS) is a promising alternative treatment for symptomatic diabetic peripheral polyneuropathy (PPN), as demonstrated in a short-term study. Based on these novel findings, we performed a prospective, nonrandomized, pilot trial in MHD patients to determine (1) whether HTEMS is also effective in treating diabetic PPN in the uremic state, and (2) whether uremic PPN is similarly modulated. Patients and Interventions In total, 40 MHD patients diagnosed with symptomatic PPN (25 with diabetic and 15 with uremic PPN) were enrolled. Both lower extremities were treated intradialytically with HTEMS for 1 hour, three times a week. Initially, a subgroup of 12 patients was followed for 4 weeks, and a further 28 patients for 12 weeks. The patients' degree of neuropathy was graded at baseline before HTEMS and after 1 and 3 months, respectively. Five neuropathic symptoms (tingling, burning, pain, numbness, and numbness in painful areas) as well as sleep disturbances were measured, using the 10-point Neuropathic Pain Scale of Galer and Jensen (Neurology 48:332-338, 1997). A positive response was defined as the improvement of one symptom or more, by at least 3 points. Other parameters included blood pressure, heart rate, dry body weight, and a routine laboratory investigation. Results The HTEMS led to a significant improvement in all five neuropathic symptoms, and to a significant reduction in sleep disturbances for both diabetic and uremic PPN. The response was independent of the patient's age, with a responder rate of 73%. The improvement of neuropathy was time-dependent, with the best results achieved after 3 months of treatment. The HTEMS was well-tolerated by nearly all patients. Conclusions This pilot study shows for the first time that HTEMS can ameliorate the discomfort and pain associated with both diabetic and uremic PPN in MHD patients, and could be a valuable supplement in the treatment of pain and neuropathic discomfort in patients who do not respond to, or are unable to participate in, exercise programs during hemodialysis treatment. Pain and peripheral neuropathy are frequent complications of end-stage renal disease (ESRD). Because drug treatment is associated with numerous side effects and is largely ineffective in many maintenance hemodialysis (MHD) patients, nonpharmacologic strategies such as electrotherapy are a potential recourse. Among various forms of electrostimulation, high-tone external muscle stimulation (HTEMS) is a promising alternative treatment for symptomatic diabetic peripheral polyneuropathy (PPN), as demonstrated in a short-term study. Based on these novel findings, we performed a prospective, nonrandomized, pilot trial in MHD patients to determine (1) whether HTEMS is also effective in treating diabetic PPN in the uremic state, and (2) whether uremic PPN is similarly modulated. In total, 40 MHD patients diagnosed with symptomatic PPN (25 with diabetic and 15 with uremic PPN) were enrolled. Both lower extremities were treated intradialytically with HTEMS for 1 hour, three times a week. Initially, a subgroup of 12 patients was followed for 4 weeks, and a further 28 patients for 12 weeks. The patients' degree of neuropathy was graded at baseline before HTEMS and after 1 and 3 months, respectively. Five neuropathic symptoms (tingling, burning, pain, numbness, and numbness in painful areas) as well as sleep disturbances were measured, using the 10-point Neuropathic Pain Scale of Galer and Jensen (Neurology 48:332-338, 1997). A positive response was defined as the improvement of one symptom or more, by at least 3 points. Other parameters included blood pressure, heart rate, dry body weight, and a routine laboratory investigation. The HTEMS led to a significant improvement in all five neuropathic symptoms, and to a significant reduction in sleep disturbances for both diabetic and uremic PPN. The response was independent of the patient's age, with a responder rate of 73%. The improvement of neuropathy was time-dependent, with the best results achieved after 3 months of treatment. The HTEMS was well-tolerated by nearly all patients. This pilot study shows for the first time that HTEMS can ameliorate the discomfort and pain associated with both diabetic and uremic PPN in MHD patients, and could be a valuable supplement in the treatment of pain and neuropathic discomfort in patients who do not respond to, or are unable to participate in, exercise programs during hemodialysis treatment." @default.
• W2012320144 created "2016-06-24" @default.
• W2012320144 creator A5013861060 @default.
• W2012320144 creator A5017413473 @default.
• W2012320144 creator A5040470420 @default.
• W2012320144 creator A5067069688 @default.
• W2012320144 creator A5067445176 @default.
• W2012320144 creator A5020415047 @default.
• W2012320144 date "2008-01-01" @default.
• W2012320144 modified "2023-10-18" @default.
• W2012320144 title "High-Tone External Muscle Stimulation in End-Stage Renal Disease: Effects on Symptomatic Diabetic and Uremic Peripheral Neuropathy" @default.
• W2012320144 cites W1968617261 @default.
• W2012320144 cites W2000975009 @default.
• W2012320144 cites W2002997737 @default.
• W2012320144 cites W2007354597 @default.
• W2012320144 cites W2015392451 @default.
• W2012320144 cites W2015728126 @default.
• W2012320144 cites W2045583944 @default.
• W2012320144 cites W2047202595 @default.
• W2012320144 cites W2057224592 @default.
• W2012320144 cites W2069133293 @default.
• W2012320144 cites W2088802136 @default.
• W2012320144 cites W2099429433 @default.
• W2012320144 cites W2101703166 @default.
• W2012320144 cites W2107176708 @default.
• W2012320144 cites W2108281489 @default.
• W2012320144 cites W2113030658 @default.
• W2012320144 cites W2125316317 @default.
• W2012320144 cites W2130070240 @default.
• W2012320144 cites W2131494662 @default.
• W2012320144 cites W2142758222 @default.
• W2012320144 cites W2159865397 @default.
• W2012320144 cites W2162322475 @default.
• W2012320144 cites W2170822995 @default.
• W2012320144 cites W2343227274 @default.
• W2012320144 doi "https://doi.org/10.1053/j.jrn.2007.10.010" @default.
• W2012320144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18089443" @default.
• W2012320144 hasPublicationYear "2008" @default.
• W2012320144 type Work @default.
• W2012320144 sameAs 2012320144 @default.
• W2012320144 citedByCount "23" @default.
• W2012320144 countsByYear W20123201442012 @default.
• W2012320144 countsByYear W20123201442013 @default.
• W2012320144 countsByYear W20123201442014 @default.
• W2012320144 countsByYear W20123201442018 @default.
• W2012320144 countsByYear W20123201442019 @default.
• W2012320144 countsByYear W20123201442022 @default.
• W2012320144 countsByYear W20123201442023 @default.
• W2012320144 crossrefType "journal-article" @default.
• W2012320144 hasAuthorship W2012320144A5013861060 @default.
• W2012320144 hasAuthorship W2012320144A5017413473 @default.
• W2012320144 hasAuthorship W2012320144A5020415047 @default.
• W2012320144 hasAuthorship W2012320144A5040470420 @default.
• W2012320144 hasAuthorship W2012320144A5067069688 @default.
• W2012320144 hasAuthorship W2012320144A5067445176 @default.
• W2012320144 hasConcept C126322002 @default.
• W2012320144 hasConcept C134018914 @default.
• W2012320144 hasConcept C141071460 @default.
• W2012320144 hasConcept C2778063415 @default.
• W2012320144 hasConcept C2779901536 @default.
• W2012320144 hasConcept C3019040382 @default.
• W2012320144 hasConcept C42219234 @default.
• W2012320144 hasConcept C46762472 @default.
• W2012320144 hasConcept C555293320 @default.
• W2012320144 hasConcept C71924100 @default.
• W2012320144 hasConcept C84393581 @default.
• W2012320144 hasConceptScore W2012320144C126322002 @default.
• W2012320144 hasConceptScore W2012320144C134018914 @default.
• W2012320144 hasConceptScore W2012320144C141071460 @default.
• W2012320144 hasConceptScore W2012320144C2778063415 @default.
• W2012320144 hasConceptScore W2012320144C2779901536 @default.
• W2012320144 hasConceptScore W2012320144C3019040382 @default.
• W2012320144 hasConceptScore W2012320144C42219234 @default.
• W2012320144 hasConceptScore W2012320144C46762472 @default.
• W2012320144 hasConceptScore W2012320144C555293320 @default.
• W2012320144 hasConceptScore W2012320144C71924100 @default.
• W2012320144 hasConceptScore W2012320144C84393581 @default.
• W2012320144 hasIssue "1" @default.
• W2012320144 hasLocation W20123201441 @default.
• W2012320144 hasLocation W20123201442 @default.
• W2012320144 hasOpenAccess W2012320144 @default.
• W2012320144 hasPrimaryLocation W20123201441 @default.
• W2012320144 hasRelatedWork W1994693750 @default.
• W2012320144 hasRelatedWork W2090531980 @default.
• W2012320144 hasRelatedWork W2127617136 @default.
• W2012320144 hasRelatedWork W2365274035 @default.
• W2012320144 hasRelatedWork W2375297571 @default.
• W2012320144 hasRelatedWork W2387422046 @default.
• W2012320144 hasRelatedWork W2405726429 @default.
• W2012320144 hasRelatedWork W2423447238 @default.
• W2012320144 hasRelatedWork W3032525078 @default.
• W2012320144 hasRelatedWork W41078410 @default.
• W2012320144 hasVolume "18" @default.
• W2012320144 isParatext "false" @default.
• W2012320144 isRetracted "false" @default.
• W2012320144 magId "2012320144" @default.
• W2012320144 workType "article" @default.