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- W2012321806 abstract "We have developed microfluidic devices with integrated active valves for an analytical biosensor system. Using polyurethane elastomers we obtained excellent sealing properties and very good chemical resistance against biological buffers and cleansing solutions. Pneumatically driven active valve structures have been integrated in the fluidic channels in order to reduce the sample volumes and to decrease the fluidic exchange times. The microfluidic devices have been fabricated by double-sided hot embossing and subsequent chemical bonding step for the fabrication of the closed channels and the valve structures. The design allows the immobilization of two different receptors on the same biochip with a 5 μl volume/sensor channel. The function of this microfluidic system with four integrated valves and two fluidic chambers has been successfully demonstrated in a bio-analytical measurement of binding of thrombin to its antibody." @default.
- W2012321806 created "2016-06-24" @default.
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- W2012321806 date "2006-04-01" @default.
- W2012321806 modified "2023-09-23" @default.
- W2012321806 title "Microfluidic devices with integrated active valves based on thermoplastic elastomers" @default.
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- W2012321806 doi "https://doi.org/10.1016/j.mee.2006.01.111" @default.
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