Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012325036> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2012325036 endingPage "107" @default.
- W2012325036 startingPage "101" @default.
- W2012325036 abstract "Histamine catabolism in vivo was studied in unanesthetized rats and guinea pigs; tissues from animals sacrificed 10 min after s.c. injection of 14C-histamine were assayed for 14C-histamine and total 14C. Groups pretreated with aminoguanidine, a diamine oxidase inhibitor, and methylhistamine, an inhibitor of the histamine-methylating enzyme, were used to evaluate roles of these enzymes in individual tissues. For rats the data suggested presence of both enzymes in intestine, diamine oxidase in lung and liver, methylation in kidney, and marked ability of heart to extract 14C-histamine from blood; these results closely check earlier data from tissues of anesthetized rats sacrificed 2.5 min after i.v. injection of 14C-histamine. For guinea pigs intestine showed evidence for both enzymes, liver and kidney for diamine oxidase, and lung and heart, for methylation. Since in animals injected with 14C-histamine, aminoguanidine pretreatment sharply reduced total 14C in mouse intestine and rat liver, another diamine oxidase inhibitor was tested; similar results were obtained. Amodiaquine, a strong inhibitor of histamine methylation in vitro, was found to inhibit in vivo. Catabolism of endogenously formed 14C-histamine was tested in the female rat, an animal which destroys exogenous histamine largely through the diamine oxidase pathway. Rats pretreated with aminoguanidine and then injected with 14C-L-histidine, excreted only slightly more 14C-histamine in urine than did controls. The ineffectiveness of aminoguanidine suggests that even in the female rat, diamine oxidase may have little significance in local catabolism of newly formed histamine. Possible reasons are discussed." @default.
- W2012325036 created "2016-06-24" @default.
- W2012325036 creator A5035502670 @default.
- W2012325036 creator A5044522506 @default.
- W2012325036 date "1974-01-01" @default.
- W2012325036 modified "2023-09-23" @default.
- W2012325036 title "Histamine catabolism in guinea pigs, rats and mice" @default.
- W2012325036 cites W1545793778 @default.
- W2012325036 cites W1940094893 @default.
- W2012325036 cites W1993180921 @default.
- W2012325036 cites W1996882894 @default.
- W2012325036 cites W2013976656 @default.
- W2012325036 cites W2026769769 @default.
- W2012325036 cites W2046653273 @default.
- W2012325036 cites W2048684492 @default.
- W2012325036 cites W2119616560 @default.
- W2012325036 cites W2123496602 @default.
- W2012325036 cites W2257273342 @default.
- W2012325036 cites W2271445967 @default.
- W2012325036 cites W2401511379 @default.
- W2012325036 doi "https://doi.org/10.1016/0014-2999(74)90100-9" @default.
- W2012325036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4215659" @default.
- W2012325036 hasPublicationYear "1974" @default.
- W2012325036 type Work @default.
- W2012325036 sameAs 2012325036 @default.
- W2012325036 citedByCount "27" @default.
- W2012325036 crossrefType "journal-article" @default.
- W2012325036 hasAuthorship W2012325036A5035502670 @default.
- W2012325036 hasAuthorship W2012325036A5044522506 @default.
- W2012325036 hasConcept C1122143 @default.
- W2012325036 hasConcept C126322002 @default.
- W2012325036 hasConcept C134018914 @default.
- W2012325036 hasConcept C150903083 @default.
- W2012325036 hasConcept C170493617 @default.
- W2012325036 hasConcept C181199279 @default.
- W2012325036 hasConcept C185592680 @default.
- W2012325036 hasConcept C187507357 @default.
- W2012325036 hasConcept C207001950 @default.
- W2012325036 hasConcept C2776885963 @default.
- W2012325036 hasConcept C2777882243 @default.
- W2012325036 hasConcept C2778102346 @default.
- W2012325036 hasConcept C2779053737 @default.
- W2012325036 hasConcept C2779183435 @default.
- W2012325036 hasConcept C2780091579 @default.
- W2012325036 hasConcept C34400551 @default.
- W2012325036 hasConcept C55493867 @default.
- W2012325036 hasConcept C71924100 @default.
- W2012325036 hasConcept C86803240 @default.
- W2012325036 hasConcept C96942376 @default.
- W2012325036 hasConceptScore W2012325036C1122143 @default.
- W2012325036 hasConceptScore W2012325036C126322002 @default.
- W2012325036 hasConceptScore W2012325036C134018914 @default.
- W2012325036 hasConceptScore W2012325036C150903083 @default.
- W2012325036 hasConceptScore W2012325036C170493617 @default.
- W2012325036 hasConceptScore W2012325036C181199279 @default.
- W2012325036 hasConceptScore W2012325036C185592680 @default.
- W2012325036 hasConceptScore W2012325036C187507357 @default.
- W2012325036 hasConceptScore W2012325036C207001950 @default.
- W2012325036 hasConceptScore W2012325036C2776885963 @default.
- W2012325036 hasConceptScore W2012325036C2777882243 @default.
- W2012325036 hasConceptScore W2012325036C2778102346 @default.
- W2012325036 hasConceptScore W2012325036C2779053737 @default.
- W2012325036 hasConceptScore W2012325036C2779183435 @default.
- W2012325036 hasConceptScore W2012325036C2780091579 @default.
- W2012325036 hasConceptScore W2012325036C34400551 @default.
- W2012325036 hasConceptScore W2012325036C55493867 @default.
- W2012325036 hasConceptScore W2012325036C71924100 @default.
- W2012325036 hasConceptScore W2012325036C86803240 @default.
- W2012325036 hasConceptScore W2012325036C96942376 @default.
- W2012325036 hasIssue "1" @default.
- W2012325036 hasLocation W20123250361 @default.
- W2012325036 hasLocation W20123250362 @default.
- W2012325036 hasOpenAccess W2012325036 @default.
- W2012325036 hasPrimaryLocation W20123250361 @default.
- W2012325036 hasRelatedWork W1590187432 @default.
- W2012325036 hasRelatedWork W1940094893 @default.
- W2012325036 hasRelatedWork W1996882894 @default.
- W2012325036 hasRelatedWork W2012325036 @default.
- W2012325036 hasRelatedWork W2013976656 @default.
- W2012325036 hasRelatedWork W2045467772 @default.
- W2012325036 hasRelatedWork W2059950392 @default.
- W2012325036 hasRelatedWork W2256714182 @default.
- W2012325036 hasRelatedWork W2415386495 @default.
- W2012325036 hasRelatedWork W326858875 @default.
- W2012325036 hasVolume "25" @default.
- W2012325036 isParatext "false" @default.
- W2012325036 isRetracted "false" @default.
- W2012325036 magId "2012325036" @default.
- W2012325036 workType "article" @default.