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- W2012334114 abstract "Norepinephrine plays a significant role in the working memory functions of the prefrontal cortex by its actions at alpha-2a noradrenergic receptors. Guanfacine has demonstrated efficacy in reversing working memory deficits in non-human primate. In the present study the effect of guanfacine adjunctive treatment to neuroleptics on the cognitive performance of schizophrenic patients was investigated in a four week, placebo-controlled, double-blind, parallel design trial. The primary analyses revealed no significant differences between guanfacine and placebo treatment; however, exploratory non-parametric statistics revealed some significant and some trend differences between guanfacine and placebo on spatial working memory test performance and CPT reaction time in those subjects treated with atypical neuroleptics." @default.
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- W2012334114 date "2001-09-01" @default.
- W2012334114 modified "2023-10-05" @default.
- W2012334114 title "Guanfacine Treatment of Cognitive Impairment in Schizophrenia" @default.
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- W2012334114 doi "https://doi.org/10.1016/s0893-133x(01)00249-4" @default.
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