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• W2012334549 abstract "During post-natal development, tendons undergo a well orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. Conversely, during the repair response to injury, structural and compositional changes occur, but in this case, a mechanically inferior tendon is produced. As a result, the process of development has been postulated as a potential paradigm through which improved adult tissue healing may occur. In this study we measured the mechanical, compositional, and structural properties in the post-natal mouse Achilles tendon at 4, 7, 10, 14, 21, and 28 days old. Throughout post-natal development, the mechanical properties, collagen content, fibril diameter mean, and fibril diameter standard deviation increased. Biglycan expression decreased and decorin expression and fiber organization were unchanged. This study provides a new mouse model that can be used to quantitatively examine mechanical development, as well as compositional and structural changes and biological mechanisms, during post-natal tendon development. This model is advantageous due to the large number of genetically modified mice and commercially available assays that are not available in other animal models. A mouse model therefore allows future mechanistic studies to build on this work." @default.
• W2012334549 created "2016-06-24" @default.
• W2012334549 creator A5014456616 @default.
• W2012334549 creator A5041113867 @default.
• W2012334549 creator A5081960106 @default.
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• W2012334549 date "2011-03-23" @default.
• W2012334549 modified "2023-10-18" @default.
• W2012334549 title "Mechanical, Compositional, and Structural Properties of the Post-natal Mouse Achilles Tendon" @default.
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• W2012334549 doi "https://doi.org/10.1007/s10439-011-0299-0" @default.
• W2012334549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3341172" @default.
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• W2012334549 hasPublicationYear "2011" @default.
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