Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012334640> ?p ?o ?g. }
- W2012334640 endingPage "276" @default.
- W2012334640 startingPage "263" @default.
- W2012334640 abstract "Chromosome synapsis during zygotene is a prerequisite for the timely homologous recombinational repair of meiotic DNA double-strand breaks (DSBs). Unrepaired DSBs are thought to trigger apoptosis during midpachytene of male meiosis if synapsis fails. An early pachytene response to asynapsis is meiotic silencing of unsynapsed chromatin (MSUC), which, in normal males, silences the X and Y chromosomes (meiotic sex chromosome inactivation [MSCI]). In this study, we show that MSUC occurs in Spo11-null mouse spermatocytes with extensive asynapsis but lacking meiotic DSBs. In contrast, three mutants (Dnmt3l, Msh5, and Dmc1) with high levels of asynapsis and numerous persistent unrepaired DSBs have a severely impaired MSUC response. We suggest that MSUC-related proteins, including the MSUC initiator BRCA1, are sequestered at unrepaired DSBs. All four mutants fail to silence the X and Y chromosomes (MSCI failure), which is sufficient to explain the midpachytene apoptosis. Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI." @default.
- W2012334640 created "2016-06-24" @default.
- W2012334640 creator A5014632478 @default.
- W2012334640 creator A5026072466 @default.
- W2012334640 creator A5031165574 @default.
- W2012334640 creator A5055162786 @default.
- W2012334640 creator A5072227443 @default.
- W2012334640 creator A5090611498 @default.
- W2012334640 date "2008-07-28" @default.
- W2012334640 modified "2023-09-30" @default.
- W2012334640 title "Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation" @default.
- W2012334640 cites W1489657805 @default.
- W2012334640 cites W1532143905 @default.
- W2012334640 cites W1540427327 @default.
- W2012334640 cites W1606401780 @default.
- W2012334640 cites W1673514954 @default.
- W2012334640 cites W1903601470 @default.
- W2012334640 cites W1971771310 @default.
- W2012334640 cites W1971887411 @default.
- W2012334640 cites W1972710550 @default.
- W2012334640 cites W1979327836 @default.
- W2012334640 cites W1980666758 @default.
- W2012334640 cites W1983844625 @default.
- W2012334640 cites W1992743727 @default.
- W2012334640 cites W1995989198 @default.
- W2012334640 cites W1996898781 @default.
- W2012334640 cites W1999479097 @default.
- W2012334640 cites W2013225037 @default.
- W2012334640 cites W2025075293 @default.
- W2012334640 cites W2031655127 @default.
- W2012334640 cites W2031743305 @default.
- W2012334640 cites W2052248785 @default.
- W2012334640 cites W2054266967 @default.
- W2012334640 cites W2054305990 @default.
- W2012334640 cites W2054859060 @default.
- W2012334640 cites W2065791212 @default.
- W2012334640 cites W2077053535 @default.
- W2012334640 cites W2080209568 @default.
- W2012334640 cites W2081213729 @default.
- W2012334640 cites W2089108779 @default.
- W2012334640 cites W2093133644 @default.
- W2012334640 cites W2096196036 @default.
- W2012334640 cites W2097323692 @default.
- W2012334640 cites W2097727084 @default.
- W2012334640 cites W2103581095 @default.
- W2012334640 cites W2111010850 @default.
- W2012334640 cites W2111760472 @default.
- W2012334640 cites W2118008591 @default.
- W2012334640 cites W2121312894 @default.
- W2012334640 cites W2126187754 @default.
- W2012334640 cites W2126679757 @default.
- W2012334640 cites W2127602493 @default.
- W2012334640 cites W2131226513 @default.
- W2012334640 cites W2143817569 @default.
- W2012334640 cites W2144190798 @default.
- W2012334640 cites W2148598128 @default.
- W2012334640 cites W2159317724 @default.
- W2012334640 cites W2163756226 @default.
- W2012334640 cites W2166523005 @default.
- W2012334640 cites W2170154905 @default.
- W2012334640 cites W2171960324 @default.
- W2012334640 cites W2286297234 @default.
- W2012334640 cites W2345994598 @default.
- W2012334640 cites W3016214204 @default.
- W2012334640 doi "https://doi.org/10.1083/jcb.200710195" @default.
- W2012334640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2483523" @default.
- W2012334640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18663141" @default.
- W2012334640 hasPublicationYear "2008" @default.
- W2012334640 type Work @default.
- W2012334640 sameAs 2012334640 @default.
- W2012334640 citedByCount "170" @default.
- W2012334640 countsByYear W20123346402012 @default.
- W2012334640 countsByYear W20123346402013 @default.
- W2012334640 countsByYear W20123346402014 @default.
- W2012334640 countsByYear W20123346402015 @default.
- W2012334640 countsByYear W20123346402016 @default.
- W2012334640 countsByYear W20123346402017 @default.
- W2012334640 countsByYear W20123346402018 @default.
- W2012334640 countsByYear W20123346402019 @default.
- W2012334640 countsByYear W20123346402020 @default.
- W2012334640 countsByYear W20123346402021 @default.
- W2012334640 countsByYear W20123346402022 @default.
- W2012334640 countsByYear W20123346402023 @default.
- W2012334640 crossrefType "journal-article" @default.
- W2012334640 hasAuthorship W2012334640A5014632478 @default.
- W2012334640 hasAuthorship W2012334640A5026072466 @default.
- W2012334640 hasAuthorship W2012334640A5031165574 @default.
- W2012334640 hasAuthorship W2012334640A5055162786 @default.
- W2012334640 hasAuthorship W2012334640A5072227443 @default.
- W2012334640 hasAuthorship W2012334640A5090611498 @default.
- W2012334640 hasBestOaLocation W20123346401 @default.
- W2012334640 hasConcept C102744134 @default.
- W2012334640 hasConcept C104317684 @default.
- W2012334640 hasConcept C148196450 @default.
- W2012334640 hasConcept C201437064 @default.
- W2012334640 hasConcept C54059333 @default.
- W2012334640 hasConcept C54355233 @default.
- W2012334640 hasConcept C552990157 @default.