FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012337116> ?p ?o ?g. }

• W2012337116 endingPage "45" @default.
• W2012337116 startingPage "33" @default.
• W2012337116 abstract "Azodicarbonamide (ADA), a HIV-1 zinc finger inhibitor, targets a new step in viral replication and cell infectivity.A first phase I/II clinical study of ADA.ADA was administered at escalating doses concomitantly with current antiviral therapy during a 3-month open-label period in patients with advanced AIDS and documented virological failure. After 3 months, patients were randomized in a double-blind placebo-controlled withdrawal, ADA being given at the highest tolerated dosage.Fifteen patients with advanced disease failing on combined antiretroviral therapy, 75% of them with proven phenotypic resistance, had a median baseline CD4 cell count of 85 x 10(6) cells/l, CD4/CD8 cell ratio of 0.09 and median plasma RNA viral load of 4.2 log10 copies/ml. Tolerance to ADA was dose dependent and some patients developed nephrolithiasis, glucose intolerance or showed an ADA-related cytotoxicity towards CD4 cells at higher dosages. No patient died during the study period. ADA increased CD4 cell percentage, increased the CD4/CD8 cell ratio and decreased plasma RNA viral load from baseline. At the end of the double-blind period, the ADA group, but not the placebo group, showed a significant response (P < 0.05). No phenotypic resistance to ADA was observed. Overall, 3/11 patients (27%) had consistent viral load reductions > 0.5 log10 copies/ml compared with baseline and 5/ 11 (45%) showed a CD4 cell recovery from baseline > 33%. In responders, ADA induced a median peak increase in CD4 cell percentage change from baseline of 65% (range 47-243%), and viral load decrease of 1.04 log10 copies/ml (range 0.52-1.23).The maximal tolerated dosage of ADA appears to be 2 g (three times daily). This study provides safety results that will allow larger clinical trials to confirm the preliminary efficacy data." @default.
• W2012337116 created "2016-06-24" @default.
• W2012337116 creator A5007143153 @default.
• W2012337116 creator A5016741562 @default.
• W2012337116 creator A5026106874 @default.
• W2012337116 creator A5027372452 @default.
• W2012337116 creator A5028104294 @default.
• W2012337116 creator A5040662398 @default.
• W2012337116 creator A5052768477 @default.
• W2012337116 creator A5054393338 @default.
• W2012337116 creator A5066053312 @default.
• W2012337116 creator A5068973466 @default.
• W2012337116 creator A5003412084 @default.
• W2012337116 date "2001-01-01" @default.
• W2012337116 modified "2023-09-27" @default.
• W2012337116 title "Phase I/II dose escalation and randomized withdrawal study with add-on azodicarbonamide in patients failing on current antiretroviral therapy" @default.
• W2012337116 cites W1543329660 @default.
• W2012337116 cites W1581447887 @default.
• W2012337116 cites W1665723380 @default.
• W2012337116 cites W1967703280 @default.
• W2012337116 cites W1969129651 @default.
• W2012337116 cites W1975121416 @default.
• W2012337116 cites W1978501067 @default.
• W2012337116 cites W1987145430 @default.
• W2012337116 cites W1988763067 @default.
• W2012337116 cites W1995347902 @default.
• W2012337116 cites W1998452579 @default.
• W2012337116 cites W2022314336 @default.
• W2012337116 cites W2024600963 @default.
• W2012337116 cites W2033939669 @default.
• W2012337116 cites W2034280823 @default.
• W2012337116 cites W2036671334 @default.
• W2012337116 cites W2037192228 @default.
• W2012337116 cites W2045444507 @default.
• W2012337116 cites W2063887787 @default.
• W2012337116 cites W2079763953 @default.
• W2012337116 cites W2080198736 @default.
• W2012337116 cites W2091535856 @default.
• W2012337116 cites W2096721638 @default.
• W2012337116 cites W2097916721 @default.
• W2012337116 cites W2098800671 @default.
• W2012337116 cites W2102696271 @default.
• W2012337116 cites W2102973576 @default.
• W2012337116 cites W2104448264 @default.
• W2012337116 cites W2130516256 @default.
• W2012337116 cites W2170109565 @default.
• W2012337116 cites W2314026148 @default.
• W2012337116 cites W2317252918 @default.
• W2012337116 cites W2339057709 @default.
• W2012337116 cites W2414449020 @default.
• W2012337116 doi "https://doi.org/10.1097/00002030-200101050-00007" @default.
• W2012337116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11192866" @default.
• W2012337116 hasPublicationYear "2001" @default.
• W2012337116 type Work @default.
• W2012337116 sameAs 2012337116 @default.
• W2012337116 citedByCount "39" @default.
• W2012337116 countsByYear W20123371162012 @default.
• W2012337116 countsByYear W20123371162014 @default.
• W2012337116 countsByYear W20123371162015 @default.
• W2012337116 countsByYear W20123371162016 @default.
• W2012337116 countsByYear W20123371162017 @default.
• W2012337116 countsByYear W20123371162018 @default.
• W2012337116 countsByYear W20123371162019 @default.
• W2012337116 countsByYear W20123371162020 @default.
• W2012337116 countsByYear W20123371162022 @default.
• W2012337116 crossrefType "journal-article" @default.
• W2012337116 hasAuthorship W2012337116A5003412084 @default.
• W2012337116 hasAuthorship W2012337116A5007143153 @default.
• W2012337116 hasAuthorship W2012337116A5016741562 @default.
• W2012337116 hasAuthorship W2012337116A5026106874 @default.
• W2012337116 hasAuthorship W2012337116A5027372452 @default.
• W2012337116 hasAuthorship W2012337116A5028104294 @default.
• W2012337116 hasAuthorship W2012337116A5040662398 @default.
• W2012337116 hasAuthorship W2012337116A5052768477 @default.
• W2012337116 hasAuthorship W2012337116A5054393338 @default.
• W2012337116 hasAuthorship W2012337116A5066053312 @default.
• W2012337116 hasAuthorship W2012337116A5068973466 @default.
• W2012337116 hasBestOaLocation W20123371161 @default.
• W2012337116 hasConcept C106358424 @default.
• W2012337116 hasConcept C126322002 @default.
• W2012337116 hasConcept C142462285 @default.
• W2012337116 hasConcept C142724271 @default.
• W2012337116 hasConcept C162156334 @default.
• W2012337116 hasConcept C167672396 @default.
• W2012337116 hasConcept C203014093 @default.
• W2012337116 hasConcept C204787440 @default.
• W2012337116 hasConcept C2522874641 @default.
• W2012337116 hasConcept C27081682 @default.
• W2012337116 hasConcept C71924100 @default.
• W2012337116 hasConcept C8891405 @default.
• W2012337116 hasConcept C90924648 @default.
• W2012337116 hasConceptScore W2012337116C106358424 @default.
• W2012337116 hasConceptScore W2012337116C126322002 @default.
• W2012337116 hasConceptScore W2012337116C142462285 @default.
• W2012337116 hasConceptScore W2012337116C142724271 @default.
• W2012337116 hasConceptScore W2012337116C162156334 @default.
• W2012337116 hasConceptScore W2012337116C167672396 @default.
• W2012337116 hasConceptScore W2012337116C203014093 @default.

• next