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• W2012340686 abstract "Staurosporine in the micromolar range raised inositol trisphosphate in intact human platelets to levels comparable to that mediated by thrombin. This response was inhibited by neomycin, a phospholipase C antagonist. Staurosporine alone induced a weak, transient rise in cytosolic free calcium levels ([Ca2+]i) from release of internal Ca2+ stores but potentiated the effect induced by thrombin. Therefore, it is unlikely that this alkaloid suppressed inositol trisphosphate mobilization of Ca2+. Additional studies show that staurosporine, 0.5-5 microM, stimulated GTPase activity in platelet membranes while 2 microM K252a and 20 microM H7 were inactive. Present results suggest that staurosporine may activate platelet phospholipase C at the level of G proteins or receptors." @default.
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• W2012340686 date "1994-04-18" @default.
• W2012340686 modified "2023-09-27" @default.
• W2012340686 title "Staurosporine induces hydrolysis of phosphatidyl inositol 4,5-bisphosphate in human platelets" @default.
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• W2012340686 doi "https://doi.org/10.1016/0014-5793(94)80602-0" @default.
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