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• W2012355247 abstract "We have been developing a computer-aided diagnostic (CAD) scheme for lung nodule detection in order to assist radiologists in the detection of lung cancer in thin-section computed tomography (CT) images.Our database consisted of 117 thin-section CT scans with 153 nodules, obtained from a lung cancer screening program at a Japanese university (85 scans, 91 nodules) and from clinical work at an American university (32 scans, 62 nodules). The database included nodules of different sizes (4-28 mm, mean 10.2 mm), shapes, and patterns (solid and ground-glass opacity (GGO)). Our CAD scheme consisted of modules for lung segmentation, selective nodule enhancement, initial nodule detection, feature extraction, and classification. The selective nodule enhancement filter was a key technique for significant enhancement of nodules and suppression of normal anatomic structures such as blood vessels, which are the main sources of false positives. Use of an automated rule-based classifier for reduction of false positives was another key technique; it resulted in a minimized overtraining effect and an improved classification performance. We used a case-based four-fold cross-validation testing method for evaluation of the performance levels of our computerized detection scheme.Our CAD scheme achieved an overall sensitivity of 86% (small: 76%, medium-sized: 94%, large: 95%; solid: 86%, mixed GGO: 89%, pure GGO: 81%) with 6.6 false positives per scan; an overall sensitivity of 81% (small: 69%, medium-sized: 91%, large: 91%; solid: 79%, mixed GGO: 88%, pure GGO: 81%) with 3.3 false positives per scan; and an overall sensitivity of 75% (small: 60%, medium-sized: 88%, large: 87%; solid: 70%, mixed GGO: 87%, pure GGO: 81%) with 1.6 false positives per scan.The experimental results indicate that our CAD scheme with its two key techniques can achieve a relatively high performance for nodules presenting large variations in size, shape, and pattern." @default.
• W2012355247 created "2016-06-24" @default.
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• W2012355247 creator A5081844561 @default.
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• W2012355247 date "2008-02-01" @default.
• W2012355247 modified "2023-10-16" @default.
• W2012355247 title "Computerized Detection of Lung Nodules in Thin-Section CT Images by Use of Selective Enhancement Filters and an Automated Rule-Based Classifier" @default.
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• W2012355247 doi "https://doi.org/10.1016/j.acra.2007.09.018" @default.
• W2012355247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2266079" @default.
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