Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012355986> ?p ?o ?g. }
- W2012355986 endingPage "322" @default.
- W2012355986 startingPage "309" @default.
- W2012355986 abstract "Abstract We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration, proposing a natural history of sequential microbial insults with predisposing host response. Proof‐of‐principle that infection can contribute to IP was provided by case studies and a placebo‐controlled efficacy study of Helicobacter eradication. “Malignant” IP appears converted to “benign”, but marked deterioration accompanies failure. Similar benefit on brady/hypokinesia from eradicating “low‐density” infection favors autoimmunity. Although a minority of UK probands are urea breath test positive for Helicobacter , the predicted probability of having the parkinsonian label depends on the serum H. pylori antibody profile, with clinically relevant gradients between this “discriminant index” and disease burden and progression. In IP, H. pylori antibodies discriminate for persistently abnormal bowel function, and specific abnormal duodenal enterocyte mitochondrial morphology is described in relation to H. pylori infection. Slow intestinal transit manifests as constipation from the prodrome. Diarrhea may flag secondary small‐intestinal bacterial overgrowth. This, coupled with genetically determined intense inflammatory response, might explain evolution from brady/hypokinetic to rigidity‐predominant parkinsonism." @default.
- W2012355986 created "2016-06-24" @default.
- W2012355986 creator A5005264312 @default.
- W2012355986 creator A5005539896 @default.
- W2012355986 creator A5007673553 @default.
- W2012355986 creator A5010969352 @default.
- W2012355986 creator A5011057158 @default.
- W2012355986 creator A5017628987 @default.
- W2012355986 creator A5025017492 @default.
- W2012355986 creator A5026855688 @default.
- W2012355986 creator A5032025013 @default.
- W2012355986 creator A5052820115 @default.
- W2012355986 creator A5063325079 @default.
- W2012355986 creator A5065866105 @default.
- W2012355986 creator A5068342745 @default.
- W2012355986 creator A5076699936 @default.
- W2012355986 creator A5087087688 @default.
- W2012355986 creator A5090612816 @default.
- W2012355986 date "2008-08-13" @default.
- W2012355986 modified "2023-10-17" @default.
- W2012355986 title "<i>Helicobacter</i>Hypothesis for Idiopathic Parkinsonism: Before and Beyond" @default.
- W2012355986 cites W1593624745 @default.
- W2012355986 cites W1664095504 @default.
- W2012355986 cites W175006040 @default.
- W2012355986 cites W1875597365 @default.
- W2012355986 cites W1923158697 @default.
- W2012355986 cites W1964010863 @default.
- W2012355986 cites W1965341361 @default.
- W2012355986 cites W1966437242 @default.
- W2012355986 cites W1966818758 @default.
- W2012355986 cites W1966918485 @default.
- W2012355986 cites W1967072964 @default.
- W2012355986 cites W1969185518 @default.
- W2012355986 cites W1970534639 @default.
- W2012355986 cites W1970760349 @default.
- W2012355986 cites W1974694466 @default.
- W2012355986 cites W1974924674 @default.
- W2012355986 cites W1976739523 @default.
- W2012355986 cites W1979453929 @default.
- W2012355986 cites W1983277933 @default.
- W2012355986 cites W1985337246 @default.
- W2012355986 cites W1985862525 @default.
- W2012355986 cites W1991511436 @default.
- W2012355986 cites W1992436728 @default.
- W2012355986 cites W1997326200 @default.
- W2012355986 cites W2001442200 @default.
- W2012355986 cites W2001464444 @default.
- W2012355986 cites W2002594841 @default.
- W2012355986 cites W2002704835 @default.
- W2012355986 cites W2010869347 @default.
- W2012355986 cites W2012769349 @default.
- W2012355986 cites W2015718711 @default.
- W2012355986 cites W2017421487 @default.
- W2012355986 cites W2018185503 @default.
- W2012355986 cites W2018393555 @default.
- W2012355986 cites W2020974804 @default.
- W2012355986 cites W2022419108 @default.
- W2012355986 cites W2024438832 @default.
- W2012355986 cites W2024590669 @default.
- W2012355986 cites W2028855344 @default.
- W2012355986 cites W2032247291 @default.
- W2012355986 cites W2035421145 @default.
- W2012355986 cites W2040096338 @default.
- W2012355986 cites W2041158634 @default.
- W2012355986 cites W2044580180 @default.
- W2012355986 cites W2050718942 @default.
- W2012355986 cites W2053126941 @default.
- W2012355986 cites W2054399253 @default.
- W2012355986 cites W2056436885 @default.
- W2012355986 cites W2063127941 @default.
- W2012355986 cites W2066203098 @default.
- W2012355986 cites W2066907732 @default.
- W2012355986 cites W2070061763 @default.
- W2012355986 cites W2071182981 @default.
- W2012355986 cites W2073449985 @default.
- W2012355986 cites W2073486423 @default.
- W2012355986 cites W2076673615 @default.
- W2012355986 cites W2086997247 @default.
- W2012355986 cites W2087581370 @default.
- W2012355986 cites W2090275483 @default.
- W2012355986 cites W2093989880 @default.
- W2012355986 cites W2104372297 @default.
- W2012355986 cites W2106022949 @default.
- W2012355986 cites W2110612501 @default.
- W2012355986 cites W2111925905 @default.
- W2012355986 cites W2116964498 @default.
- W2012355986 cites W2120323573 @default.
- W2012355986 cites W2150963490 @default.
- W2012355986 cites W2155395884 @default.
- W2012355986 cites W2162373315 @default.
- W2012355986 cites W2165339984 @default.
- W2012355986 cites W2165976376 @default.
- W2012355986 cites W2339380718 @default.
- W2012355986 cites W2974481526 @default.
- W2012355986 cites W3021976379 @default.
- W2012355986 cites W37005 @default.
- W2012355986 cites W4245113130 @default.
- W2012355986 cites W4294570573 @default.