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- W2012357103 endingPage "1863" @default.
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- W2012357103 abstract "The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors." @default.
- W2012357103 created "2016-06-24" @default.
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- W2012357103 date "1998-09-18" @default.
- W2012357103 modified "2023-10-14" @default.
- W2012357103 title "Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx" @default.
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- W2012357103 doi "https://doi.org/10.1126/science.281.5384.1860" @default.
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