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- W2012357110 abstract "To examine the relationship between D90 (the minimum dose received by 90% of the post-implant CT based prostate volume) and PSA control in patients treated with I125 LDR prostate brachytherapy with follow-up of at least five years. Between March 1995 and September 2007, 2157 consecutive patients with localized prostate cancer underwent I-125 permanent prostate brachytherapy as monotherapy in a single centre. All patients were TRUS planned delivering 145 Gy (TG 43) and implanted using stranded seeds. None received supplemental external beam radiation therapy. Post implant CT based dosimetry was available for 711 (33%). Outcomes were analysed in terms of relation of D90 to PSA relapse free survival (Nadir 2+). For the cohort with post-implant dosimetry, 348 (49%) were low risk, 292 (41%) intermediate risk and 71 (10%) were high risk as defined by MSK model. Mean D90 was 138Gy (SD 24.6Gy) and median 140Gy (range 59-200Gy). Biochemical control at 10 years was achieved in 76% of patients with D(90) > 140 Gy and in 68% with D(90) <140 Gy (p <0.01). This difference was seen in all risk groups. A D90 value of less than 140Gy is predictive of increased risk of biochemical failure 10 years after I-125 brachytherapy across risk groups." @default.
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- W2012357110 date "2014-09-01" @default.
- W2012357110 modified "2023-10-18" @default.
- W2012357110 title "Impact of D90 on PSA Outcomes in Men Treated With Low-Dose-Rate Prostate I125 Monotherapy" @default.
- W2012357110 doi "https://doi.org/10.1016/j.ijrobp.2014.05.1410" @default.
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