Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012358978> ?p ?o ?g. }
- W2012358978 abstract "Abstract Microtubules are dynamic polymers that occur in eukaryotic cells and play important roles in cell division, motility, transport and signaling. They form during the process of polymerization of α- and β-tubulin dimers. Tubulin is a significant and heavily researched molecular target for anticancer drugs. Combretastatins are natural cis-stilbenes that exhibit cytotoxic properties in cultured cancer cells in vitro. Combretastatin A-4 (3′-hydroxy-3,4,4′, 5-tetramethoxy-cis-stilbene; CA-4) is a potent cytotoxic cis-stilbene that binds to β-tubulin at the colchicine-binding site and inhibits tubulin polymerization. The prodrug CA-4 phosphate is currently in clinical trials as a chemotherapeutic agent for cancer treatment. Numerous series of stilbene analogs have been studied in search of potent cytotoxic agents with the requisite tubulin-interactive properties. Microtubule-interfering agents include numerous CA-4 and transresveratrol analogs and other synthetic stilbene derivatives. Importantly, these agents are active in both tumor cells and immature endothelial cells of tumor blood vessels, where they inhibit the process of angiogenesis. Recently, computer-aided virtual screening was used to select potent tubulin-interactive compounds. This review covers the role of stilbene derivatives as a class of antitumor agents that act by targeting microtubule assembly dynamics. Additionally, we present the results of molecular modeling of their binding to specific sites on the α- and β-tubulin heterodimer. This has enabled the elucidation of the mechanism of stilbene cytotoxicity and is useful in the design of novel agents with improved anti-mitotic activity. Tubulin-interactive agents are believed to have the potential to play a significant role in the fight against cancer." @default.
- W2012358978 created "2016-06-24" @default.
- W2012358978 creator A5006579529 @default.
- W2012358978 creator A5052739109 @default.
- W2012358978 creator A5089834624 @default.
- W2012358978 date "2013-01-01" @default.
- W2012358978 modified "2023-10-15" @default.
- W2012358978 title "Tubulin-interactive stilbene derivatives as anticancer agents" @default.
- W2012358978 cites W1516443096 @default.
- W2012358978 cites W1725865716 @default.
- W2012358978 cites W1963878289 @default.
- W2012358978 cites W1966281939 @default.
- W2012358978 cites W1966813923 @default.
- W2012358978 cites W1967132936 @default.
- W2012358978 cites W1970199745 @default.
- W2012358978 cites W1971579914 @default.
- W2012358978 cites W1974934240 @default.
- W2012358978 cites W1979859900 @default.
- W2012358978 cites W1985501881 @default.
- W2012358978 cites W1987130723 @default.
- W2012358978 cites W1989799657 @default.
- W2012358978 cites W1991707369 @default.
- W2012358978 cites W1994089494 @default.
- W2012358978 cites W1994297035 @default.
- W2012358978 cites W1994345832 @default.
- W2012358978 cites W1996145189 @default.
- W2012358978 cites W1999236504 @default.
- W2012358978 cites W1999306309 @default.
- W2012358978 cites W2000756009 @default.
- W2012358978 cites W2001632155 @default.
- W2012358978 cites W2002550232 @default.
- W2012358978 cites W2006993970 @default.
- W2012358978 cites W2007869047 @default.
- W2012358978 cites W2008013665 @default.
- W2012358978 cites W2008266049 @default.
- W2012358978 cites W2008684962 @default.
- W2012358978 cites W2012586906 @default.
- W2012358978 cites W2012750862 @default.
- W2012358978 cites W2012782068 @default.
- W2012358978 cites W2015082085 @default.
- W2012358978 cites W2017246015 @default.
- W2012358978 cites W2021101729 @default.
- W2012358978 cites W2022486586 @default.
- W2012358978 cites W2024302518 @default.
- W2012358978 cites W2024304301 @default.
- W2012358978 cites W2027330514 @default.
- W2012358978 cites W2031659792 @default.
- W2012358978 cites W2034242236 @default.
- W2012358978 cites W2035210263 @default.
- W2012358978 cites W2038584353 @default.
- W2012358978 cites W2042351695 @default.
- W2012358978 cites W2042935086 @default.
- W2012358978 cites W2044750332 @default.
- W2012358978 cites W2050344391 @default.
- W2012358978 cites W2051628747 @default.
- W2012358978 cites W2054341244 @default.
- W2012358978 cites W2056438029 @default.
- W2012358978 cites W2056829846 @default.
- W2012358978 cites W2064571598 @default.
- W2012358978 cites W2066678132 @default.
- W2012358978 cites W2075039221 @default.
- W2012358978 cites W2075351483 @default.
- W2012358978 cites W2075990374 @default.
- W2012358978 cites W2077764145 @default.
- W2012358978 cites W2079445842 @default.
- W2012358978 cites W2079641700 @default.
- W2012358978 cites W2079967197 @default.
- W2012358978 cites W2080643084 @default.
- W2012358978 cites W2081938650 @default.
- W2012358978 cites W2083061986 @default.
- W2012358978 cites W2087793839 @default.
- W2012358978 cites W2093313172 @default.
- W2012358978 cites W2096001845 @default.
- W2012358978 cites W2096487429 @default.
- W2012358978 cites W2100906891 @default.
- W2012358978 cites W2102950926 @default.
- W2012358978 cites W2103820777 @default.
- W2012358978 cites W2104178524 @default.
- W2012358978 cites W2105091840 @default.
- W2012358978 cites W2105718579 @default.
- W2012358978 cites W2107781646 @default.
- W2012358978 cites W2111374072 @default.
- W2012358978 cites W2114462603 @default.
- W2012358978 cites W2125240364 @default.
- W2012358978 cites W2126683450 @default.
- W2012358978 cites W2128560067 @default.
- W2012358978 cites W2134634408 @default.
- W2012358978 cites W2135783745 @default.
- W2012358978 cites W2144446057 @default.
- W2012358978 cites W2145438844 @default.
- W2012358978 cites W2145516891 @default.
- W2012358978 cites W2148066280 @default.
- W2012358978 cites W2149882720 @default.
- W2012358978 cites W2150433496 @default.
- W2012358978 cites W2152574565 @default.
- W2012358978 cites W2153739394 @default.
- W2012358978 cites W2154587590 @default.
- W2012358978 cites W2155068104 @default.
- W2012358978 cites W2156701913 @default.
- W2012358978 cites W2157319245 @default.