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- W2012364322 endingPage "6885" @default.
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- W2012364322 abstract "Although allogeneic islet transplantation can successfully cure type 1 diabetes, it has limited applicability. For example, organs are in short supply; several human pancreas donors are often needed to treat one diabetic recipient; the intrahepatic site may not be the most appropriate site for islet implantation; and immunosuppressive regimens, which are associated with side effects, are often required to prolong survival of the islet graft. An alternative source of insulin-producing cells would therefore be of major interest. Pigs represent a possible alternative source of beta cells. Grafting of pig islets may appear difficult because of the immunologic species barrier, but pig islets have been shown to function in primates for at least 6 mo with clinically incompatible immunosuppression. Therefore, a bioartificial pancreas made of encapsulated pig islets may resolve issues associated with islet allotransplantation. Although several groups have shown that encapsulated pig islets are functional in small-animal models, less is known about the use of bioartificial pancreases in large-animal models. In this review, we summarize current knowledge of encapsulated pig islets, to determine obstacles to implantation in humans and possible solutions to overcome these obstacles." @default.
- W2012364322 created "2016-06-24" @default.
- W2012364322 creator A5040582776 @default.
- W2012364322 creator A5048109458 @default.
- W2012364322 date "2012-01-01" @default.
- W2012364322 modified "2023-09-23" @default.
- W2012364322 title "Macro- or microencapsulation of pig islets to cure type 1 diabetes" @default.
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- W2012364322 doi "https://doi.org/10.3748/wjg.v18.i47.6885" @default.
- W2012364322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3531671" @default.
- W2012364322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23322985" @default.
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