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• W2012364885 startingPage "119" @default.
• W2012364885 abstract "Treatment of Freund's complete adjuvant sensitised rats with PGE1 (1.5 mg/kg/day), on days 6–13 after sensitization, or feeding them an essential fatty acid deficient (EFAD) diet, both enhanced the delayed hypersensitivity (DH) response to purified protein derivative of tuberculin (PPD), measured following transfer of donor lymph node cells into syngeneic recipients. The effect of EFA deficiency was more marked than that of PGE1. In vitro preincubation of lymph node cells obtained from sensitised rats with PGE1 (1 μg/ml) for 10 min, 2 h or 19 h also enhanced the subsequent transfer of DH to PPD. Lower doses of PGE1 were without effect after 10 min incubation. A single 100 μg dose of PGE1, given 24 h before transfer of spleen cells from mice sensitised with sheep red blood cells (SRBC), diminished the subsequent development of the DH response to SRBC in recipient mice. The primary DH response was inhibited more markedly than the secondary response. The results with PGE1 in rats confirm earlier results of other authors on the effects of PGE1 given directly to rats and guinea pigs in which a state of DH to PPD was established. It is suggested that PGE1 may act either through a cyclic AMP-mediated stimulation of a subpopulation of T-lymphocytes or via inhibition of T-suppressor cells activated by PPD. The results with EFAD rats are most likely attributable to removal of an inhibitory effect of EFAs per se on T-lymphocyte activation. The effects of PGE1 on DH to SRBC in mice confirm other data on the inhibitory effects of this PG on lymphocyte function and clearly indicate a difference in the effect of PGE1 on different models of DH." @default.
• W2012364885 created "2016-06-24" @default.
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• W2012364885 date "1979-01-01" @default.
• W2012364885 modified "2023-09-25" @default.
• W2012364885 title "Enhancement by prostaglandin E1 and essential fatty acid deficiency of the passive transfer of delayed hypersensitivity to PPD in rats. Comparison with effects on delayed hypersensitivity to SRBC in mice" @default.
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• W2012364885 doi "https://doi.org/10.1016/0192-0561(79)90014-6" @default.
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