FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012365613> ?p ?o ?g. }

• W2012365613 endingPage "e106821" @default.
• W2012365613 startingPage "e106821" @default.
• W2012365613 abstract "Dysfunctional pulmonary homeostasis and repair, including diseases such as pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), and tumorigenesis have been increasing over the past decade, a fact that heavily implicates environmental influences. Several investigations have suggested that in response to increased transforming growth factor - beta (TGFβ) signaling, the alveolar type II (ATII) epithelial cell undergoes phenotypic changes that may contribute to the complex pathobiology of PF. We have previously demonstrated that increased tissue stiffness associated with PF is a potent extracellular matrix (ECM) signal for epithelial cell activation of TGFβ. The work reported here explores the relationship between tissue stiffness and exposure to environmental stimuli in the activation of TGFβ. We hypothesized that exposure of ATII cells to fine particulate matter (PM2.5) will result in enhanced cell contractility, TGFβ activation, and subsequent changes to ATII cell phenotype. ATII cells were cultured on increasingly stiff substrates with or without addition of PM2.5. Exposure to PM2.5 resulted in increased activation of TGFβ, increased cell contractility, and elongation of ATII cells. Most notably, on 8 kPa substrates, a stiffness greater than normal but less than established fibrotic lung, addition of PM2.5 resulted in increased cortical cell stiffness, enhanced actin staining and cell elongation; a result not seen in the absence of PM2.5. Our work suggests that PM2.5 exposure additionally enhances the existing interaction between ECM stiffness and TGFβ that has been previously reported. Furthermore, we show that this additional enhancement is likely a consequence of intracellular reactive oxygen species (ROS) leading to increased TGFβ signaling events. These results highlight the importance of both the micromechanical and biochemical environment in lung disease initiation and suggest that individuals in early stages of lung remodeling during fibrosis may be more susceptible than healthy individuals when exposed to environmental injury adjuvants." @default.
• W2012365613 created "2016-06-24" @default.
• W2012365613 creator A5031205472 @default.
• W2012365613 creator A5067004889 @default.
• W2012365613 creator A5071579133 @default.
• W2012365613 creator A5073026508 @default.
• W2012365613 date "2014-09-16" @default.
• W2012365613 modified "2023-10-16" @default.
• W2012365613 title "Environmental Particulate (PM2.5) Augments Stiffness-Induced Alveolar Epithelial Cell Mechanoactivation of Transforming Growth Factor Beta" @default.
• W2012365613 cites W1497005060 @default.
• W2012365613 cites W1502147118 @default.
• W2012365613 cites W1549251297 @default.
• W2012365613 cites W1575754639 @default.
• W2012365613 cites W1950871050 @default.
• W2012365613 cites W1951049964 @default.
• W2012365613 cites W1965933207 @default.
• W2012365613 cites W1972187255 @default.
• W2012365613 cites W1973089587 @default.
• W2012365613 cites W1980325398 @default.
• W2012365613 cites W1985121054 @default.
• W2012365613 cites W1988093972 @default.
• W2012365613 cites W1990218742 @default.
• W2012365613 cites W1992044002 @default.
• W2012365613 cites W1994185723 @default.
• W2012365613 cites W1994836525 @default.
• W2012365613 cites W1995063875 @default.
• W2012365613 cites W1995592152 @default.
• W2012365613 cites W1998975199 @default.
• W2012365613 cites W2002582091 @default.
• W2012365613 cites W2002901364 @default.
• W2012365613 cites W2004710474 @default.
• W2012365613 cites W2007691559 @default.
• W2012365613 cites W2016382510 @default.
• W2012365613 cites W2018822666 @default.
• W2012365613 cites W2025368483 @default.
• W2012365613 cites W2026067647 @default.
• W2012365613 cites W2031018453 @default.
• W2012365613 cites W2031938767 @default.
• W2012365613 cites W2033260397 @default.
• W2012365613 cites W2048035811 @default.
• W2012365613 cites W2051019986 @default.
• W2012365613 cites W2052626837 @default.
• W2012365613 cites W2058611314 @default.
• W2012365613 cites W2060126259 @default.
• W2012365613 cites W2062461864 @default.
• W2012365613 cites W2069760800 @default.
• W2012365613 cites W2075557704 @default.
• W2012365613 cites W2079913317 @default.
• W2012365613 cites W2080452175 @default.
• W2012365613 cites W2099052265 @default.
• W2012365613 cites W2099285472 @default.
• W2012365613 cites W2099585656 @default.
• W2012365613 cites W2100113004 @default.
• W2012365613 cites W2101466169 @default.
• W2012365613 cites W2102024523 @default.
• W2012365613 cites W2104778949 @default.
• W2012365613 cites W2109398776 @default.
• W2012365613 cites W2110777286 @default.
• W2012365613 cites W2112195516 @default.
• W2012365613 cites W2117444024 @default.
• W2012365613 cites W2124836468 @default.
• W2012365613 cites W2128231056 @default.
• W2012365613 cites W2129308384 @default.
• W2012365613 cites W2130146821 @default.
• W2012365613 cites W2131944618 @default.
• W2012365613 cites W2134208433 @default.
• W2012365613 cites W2138907055 @default.
• W2012365613 cites W2150102283 @default.
• W2012365613 cites W2152943144 @default.
• W2012365613 cites W2154086186 @default.
• W2012365613 cites W2154568166 @default.
• W2012365613 cites W2155118487 @default.
• W2012365613 cites W2156036748 @default.
• W2012365613 cites W2156624266 @default.
• W2012365613 cites W2158075507 @default.
• W2012365613 cites W2160912589 @default.
• W2012365613 cites W2167243609 @default.
• W2012365613 cites W2169046198 @default.
• W2012365613 cites W2170331002 @default.
• W2012365613 cites W2172237567 @default.
• W2012365613 cites W4294352168 @default.
• W2012365613 doi "https://doi.org/10.1371/journal.pone.0106821" @default.
• W2012365613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4167324" @default.
• W2012365613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25226160" @default.
• W2012365613 hasPublicationYear "2014" @default.
• W2012365613 type Work @default.
• W2012365613 sameAs 2012365613 @default.
• W2012365613 citedByCount "43" @default.
• W2012365613 countsByYear W20123656132016 @default.
• W2012365613 countsByYear W20123656132017 @default.
• W2012365613 countsByYear W20123656132018 @default.
• W2012365613 countsByYear W20123656132019 @default.
• W2012365613 countsByYear W20123656132020 @default.
• W2012365613 countsByYear W20123656132021 @default.
• W2012365613 countsByYear W20123656132022 @default.
• W2012365613 countsByYear W20123656132023 @default.
• W2012365613 crossrefType "journal-article" @default.
• W2012365613 hasAuthorship W2012365613A5031205472 @default.

• next