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- W2012373405 abstract "Pathology, University of Washington,Seattle, WashingtonIntroduction: Urothelial cancer is on the rise. The relatively longersurvival is attributed to timely diagnosis and effective clinical manage-ment. The role of urinary cytology is central in the continued surveillanceand cannot be over-emphasized. In literature urine cytology has a muchhigher sensitivity and specificity for high grade urothelial carcinomaapproaching 75%-98%, when compared to 8.5 to 50% for low-gradelesions.The objective of our study was to review and benchmark the accuracy ofurine cytology and risk of malignancy (predicted probability) for every urinecytology diagnostic category.Materials and Methods: A laboratory information system search (Cernerand Meditech) retrieved 443 GU biopsies along with their preceding 920urine cytologies from January 2008 to January 2011. Statistical analysiswas performed using the cytology specimen within 6 months and closestto biopsy date and more than 6 months and farthest from the biopsy date.Cytology diagnostic categories included negative for malignant cells(NMC) (N Z 183), reactive cellular change (RCC) (N Z 15), atypical(A) (N Z 77), suspicious(S) (N Z 38) and positive (P) (N Z 61). NMCand RCC were classified as negative. All other categories wereconsidered positive. Logistic regression was used to model malignancyas a function of urine cytology diagnostic category within 6 months frombiopsy.Results: The overall sensitivity and specificity of urine cytology was 62.8%and 74.2% respectively (Table 1). Sensitivity for high grade lesions wasgreater (71.6%) than that for low grade (46.3%). Sensitivity for both highgrade and low grade lesions was similar before and after 6 months but spec-ificity declined after 6 months (Table 3). The risk of malignancy was highfor positive, suspicious and atypical categories at 0.82, 0.82 and 0.7 respec-tively (Table 2)." @default.
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- W2012373405 date "2012-11-01" @default.
- W2012373405 modified "2023-09-26" @default.
- W2012373405 title "Review of Accuracy of Urinary Cytology with Risk of Malignancy Assessment per Cytology Categories in a Large Tertiary Health Care System" @default.
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- W2012373405 doi "https://doi.org/10.1016/j.jasc.2012.08.050" @default.
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