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- W2012374172 abstract "Two mesophilic/thermophilic variants of the G-domain of the elongation factor Tu were studied via molecular dynamics simulations. By analyzing the simulation data via the Voronoi space tessellation, we have found that the two proteins have the same macromolecular packing, while the water-exposed surface area is larger for the thermophile. A larger coordination with water is probably due to a peculiar corrugation of the exposed surface of this species. From an enthalpic point of view, the thermophile shows a larger number of intramolecular hydrogen bonds, stronger electrostatic interactions, and a flatter free-energy landscape. Overall, the data suggest that the specific hydration state enhances macromolecular fluctuations but, at the same time, increases thermal stability." @default.
- W2012374172 created "2016-06-24" @default.
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- W2012374172 date "2006-06-01" @default.
- W2012374172 modified "2023-09-26" @default.
- W2012374172 title "Explanation of the Stability of Thermophilic Proteins Based on Unique Micromorphology" @default.
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- W2012374172 doi "https://doi.org/10.1529/biophysj.105.078972" @default.
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