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- W2012375413 endingPage "424" @default.
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- W2012375413 abstract "ApoE is a key protein in lipid metabolism with three major isoforms. ApoE allele frequencies show non-random global distribution especially in Europe with high apoE ε 3 frequency in the Mediterranean area, whereas the apoE ε 4 genotype is enriched in Northern Europe. The apoE ε 4 genotype is one of the most important genetic risk factors for age-dependent chronic diseases, including CVD and Alzheimer's disease (AD). The apoE polymorphism has been shown to impact on blood lipids, biomarkers of oxidative stress and chronic inflammation, which all may contribute to the isoform-dependent disease risk. Studies in mice and human subjects indicate that the apoE ε 3 but not the apoE ε 4 genotype may significantly benefit from dietary flavonoids (e.g. quercetin) and n -3 fatty acids. Metabolism of lipid soluble vitamins E and D is likewise differentially affected by the apoE genotype. Epidemiological and experimental evidence suggest a better vitamin D status in apoE ε 4 than ε 3 subjects indicating a certain advantage of ε 4 over ε 3 . The present review aims at evaluation of current data available on interactions between apoE polymorphism and dietary responsiveness to flavonoids, fat soluble vitamins and n -3 fatty acids. Likewise, distinct geographic distribution and chronic disease risk of the different apoE isoforms are addressed." @default.
- W2012375413 created "2016-06-24" @default.
- W2012375413 creator A5054741610 @default.
- W2012375413 creator A5082605152 @default.
- W2012375413 creator A5088330093 @default.
- W2012375413 date "2012-05-08" @default.
- W2012375413 modified "2023-10-18" @default.
- W2012375413 title "ApoE genotype: from geographic distribution to function and responsiveness to dietary factors" @default.
- W2012375413 cites W1488147530 @default.
- W2012375413 cites W1498570643 @default.
- W2012375413 cites W1500145074 @default.
- W2012375413 cites W1546262989 @default.
- W2012375413 cites W1559121591 @default.
- W2012375413 cites W1823351839 @default.
- W2012375413 cites W1944481812 @default.
- W2012375413 cites W1949465911 @default.
- W2012375413 cites W1955787339 @default.
- W2012375413 cites W1964444802 @default.
- W2012375413 cites W1966515201 @default.
- W2012375413 cites W1966721630 @default.
- W2012375413 cites W1969101327 @default.
- W2012375413 cites W1973065853 @default.
- W2012375413 cites W1973754944 @default.
- W2012375413 cites W1984737558 @default.
- W2012375413 cites W1985193176 @default.
- W2012375413 cites W1985859760 @default.
- W2012375413 cites W1986364810 @default.
- W2012375413 cites W1986703630 @default.
- W2012375413 cites W1987604596 @default.
- W2012375413 cites W1987968562 @default.
- W2012375413 cites W1988385409 @default.
- W2012375413 cites W1990170200 @default.
- W2012375413 cites W1999476309 @default.
- W2012375413 cites W2003854546 @default.
- W2012375413 cites W2006835455 @default.
- W2012375413 cites W2007213176 @default.
- W2012375413 cites W2007421495 @default.
- W2012375413 cites W2008099488 @default.
- W2012375413 cites W2009069392 @default.
- W2012375413 cites W2012989429 @default.
- W2012375413 cites W2013790832 @default.
- W2012375413 cites W2013863433 @default.
- W2012375413 cites W2015372700 @default.
- W2012375413 cites W2018109459 @default.
- W2012375413 cites W2018466298 @default.
- W2012375413 cites W2020877938 @default.
- W2012375413 cites W2022456632 @default.
- W2012375413 cites W2030153215 @default.
- W2012375413 cites W2031254675 @default.
- W2012375413 cites W2035029099 @default.
- W2012375413 cites W2036362108 @default.
- W2012375413 cites W2038003193 @default.
- W2012375413 cites W2041864499 @default.
- W2012375413 cites W2045317765 @default.
- W2012375413 cites W2046431596 @default.
- W2012375413 cites W2047222949 @default.
- W2012375413 cites W2056212035 @default.
- W2012375413 cites W2056631437 @default.
- W2012375413 cites W2057640413 @default.
- W2012375413 cites W2057933641 @default.
- W2012375413 cites W2058034919 @default.
- W2012375413 cites W2061116750 @default.
- W2012375413 cites W2061530946 @default.
- W2012375413 cites W2061647500 @default.
- W2012375413 cites W2062218710 @default.
- W2012375413 cites W2065859331 @default.
- W2012375413 cites W2066644955 @default.
- W2012375413 cites W2066718767 @default.
- W2012375413 cites W2067160010 @default.
- W2012375413 cites W2069863984 @default.
- W2012375413 cites W2072459924 @default.
- W2012375413 cites W2075539642 @default.
- W2012375413 cites W2075983009 @default.
- W2012375413 cites W2077302414 @default.
- W2012375413 cites W2077399174 @default.
- W2012375413 cites W2078882205 @default.
- W2012375413 cites W2080777317 @default.
- W2012375413 cites W2081863934 @default.
- W2012375413 cites W2082256868 @default.
- W2012375413 cites W2083200677 @default.
- W2012375413 cites W2086641848 @default.
- W2012375413 cites W2091362488 @default.
- W2012375413 cites W2092818456 @default.
- W2012375413 cites W2093497534 @default.
- W2012375413 cites W2093662767 @default.
- W2012375413 cites W2094546345 @default.
- W2012375413 cites W2096142564 @default.
- W2012375413 cites W2096313916 @default.
- W2012375413 cites W2098705946 @default.
- W2012375413 cites W2100023507 @default.
- W2012375413 cites W2101172397 @default.
- W2012375413 cites W2103105920 @default.
- W2012375413 cites W2105102381 @default.
- W2012375413 cites W2105776190 @default.
- W2012375413 cites W2106611664 @default.
- W2012375413 cites W2112251329 @default.
- W2012375413 cites W2112412246 @default.
- W2012375413 cites W2113562559 @default.