Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012376621> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2012376621 abstract "It is argued that immunotherapy (IMTH) for cancer, as well as the theory of cancer immunogenicity on which it rests, derives no secure foundation either from clinical observations or from experimental study of valid animal tumour models. Discouraging clinical observations include: the long history of failure of IMTH; the rejection of IMTH for choriocarcinoma--a true allograft in the patient; the extreme rarity of spontaneous regression, and progressive discrediting of the theory of immunosurveillance; the high frequency of nodal metastasis; and the failure to demonstrate a tumour-specific antigen in man. The great majority of animal tumours used for experimental studies of IMTH display artefactual immunogenicity associated with their mode of induction or conditions of transplantation and cannot be accepted as valid models of clinical cancer. The author reviews his total failure to demonstrate immunogenicity or successful IMTH using a wide range of animal tumours from which known laboratory artefacts have been strictly excluded. The inordinate promotion of tumour immunology and IMTH in recent years is attributed to unfortunate sociological influences encouraging premature assertion of clinical relevance from experimental research." @default.
- W2012376621 created "2016-06-24" @default.
- W2012376621 creator A5064812389 @default.
- W2012376621 date "1979-01-01" @default.
- W2012376621 modified "2023-09-23" @default.
- W2012376621 title "A critical examination of the foundations of immunotherapy for cancer" @default.
- W2012376621 cites W1482528249 @default.
- W2012376621 cites W1526082783 @default.
- W2012376621 cites W1553686702 @default.
- W2012376621 cites W1569343374 @default.
- W2012376621 cites W1971460598 @default.
- W2012376621 cites W1971539939 @default.
- W2012376621 cites W1980868141 @default.
- W2012376621 cites W1990163451 @default.
- W2012376621 cites W1996840866 @default.
- W2012376621 cites W1997637117 @default.
- W2012376621 cites W2000475904 @default.
- W2012376621 cites W2009209888 @default.
- W2012376621 cites W2009818354 @default.
- W2012376621 cites W2019585055 @default.
- W2012376621 cites W2019648272 @default.
- W2012376621 cites W2025048581 @default.
- W2012376621 cites W2031344400 @default.
- W2012376621 cites W2038440293 @default.
- W2012376621 cites W2038442693 @default.
- W2012376621 cites W2044798843 @default.
- W2012376621 cites W2058637527 @default.
- W2012376621 cites W2061798711 @default.
- W2012376621 cites W2064135404 @default.
- W2012376621 cites W2067453140 @default.
- W2012376621 cites W2074061932 @default.
- W2012376621 cites W2078794379 @default.
- W2012376621 cites W2124659056 @default.
- W2012376621 cites W2154894027 @default.
- W2012376621 cites W2159203898 @default.
- W2012376621 cites W2258458523 @default.
- W2012376621 cites W2418879774 @default.
- W2012376621 cites W2462503674 @default.
- W2012376621 cites W2566347824 @default.
- W2012376621 cites W2913360484 @default.
- W2012376621 doi "https://doi.org/10.1016/s0009-9260(79)80209-3" @default.
- W2012376621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/572751" @default.
- W2012376621 hasPublicationYear "1979" @default.
- W2012376621 type Work @default.
- W2012376621 sameAs 2012376621 @default.
- W2012376621 citedByCount "35" @default.
- W2012376621 countsByYear W20123766212015 @default.
- W2012376621 countsByYear W20123766212017 @default.
- W2012376621 crossrefType "journal-article" @default.
- W2012376621 hasAuthorship W2012376621A5064812389 @default.
- W2012376621 hasConcept C121608353 @default.
- W2012376621 hasConcept C126322002 @default.
- W2012376621 hasConcept C141071460 @default.
- W2012376621 hasConcept C147483822 @default.
- W2012376621 hasConcept C203014093 @default.
- W2012376621 hasConcept C2776885095 @default.
- W2012376621 hasConcept C2777701055 @default.
- W2012376621 hasConcept C2780674031 @default.
- W2012376621 hasConcept C2780868878 @default.
- W2012376621 hasConcept C2911091166 @default.
- W2012376621 hasConcept C71924100 @default.
- W2012376621 hasConceptScore W2012376621C121608353 @default.
- W2012376621 hasConceptScore W2012376621C126322002 @default.
- W2012376621 hasConceptScore W2012376621C141071460 @default.
- W2012376621 hasConceptScore W2012376621C147483822 @default.
- W2012376621 hasConceptScore W2012376621C203014093 @default.
- W2012376621 hasConceptScore W2012376621C2776885095 @default.
- W2012376621 hasConceptScore W2012376621C2777701055 @default.
- W2012376621 hasConceptScore W2012376621C2780674031 @default.
- W2012376621 hasConceptScore W2012376621C2780868878 @default.
- W2012376621 hasConceptScore W2012376621C2911091166 @default.
- W2012376621 hasConceptScore W2012376621C71924100 @default.
- W2012376621 hasLocation W20123766211 @default.
- W2012376621 hasLocation W20123766212 @default.
- W2012376621 hasOpenAccess W2012376621 @default.
- W2012376621 hasPrimaryLocation W20123766211 @default.
- W2012376621 hasRelatedWork W1517312530 @default.
- W2012376621 hasRelatedWork W196904668 @default.
- W2012376621 hasRelatedWork W2008529945 @default.
- W2012376621 hasRelatedWork W2068909737 @default.
- W2012376621 hasRelatedWork W2770116943 @default.
- W2012376621 hasRelatedWork W3081914432 @default.
- W2012376621 hasRelatedWork W3149203513 @default.
- W2012376621 hasRelatedWork W3154696046 @default.
- W2012376621 hasRelatedWork W4229450900 @default.
- W2012376621 hasRelatedWork W4281477545 @default.
- W2012376621 isParatext "false" @default.
- W2012376621 isRetracted "false" @default.
- W2012376621 magId "2012376621" @default.
- W2012376621 workType "article" @default.