FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012377587> ?p ?o ?g. }

• W2012377587 endingPage "2051" @default.
• W2012377587 startingPage "2045" @default.
• W2012377587 abstract "There is limited evidence about longer-term effects of combination antiretroviral therapy that includes protease inhibitors (PIs) on the immunological status of HIV-1-infected children. Better understanding might help to resolve questions on when to initiate treatment.The change in percentage of CD4-positive T lymphocytes (CD4%) was investigated in 1012 previously treated HIV-1-infected children (aged 0-17 years) who were enrolled in research clinics in the USA before 1996 and followed up to 2000. 702 started PI-based combination therapy. Data analyses ignored subsequent treatment changes.Among the 1012 children, the median CD4% increased from 22% to 28% between 1996, when PIs were first prescribed, and 2000. For the 702 who started PI-based therapy, the mean CD4% increase after 3 years was largest among participants with the greatest immunosuppression (15.7%, 10.6%, 5.1%, and 2.0% for participants with CD4% before therapy of <5%, 5-14%, 15-24%, and >25%; p<0.0001). After adjustment for pre-PI CD4%, the mean increase was largest among the youngest participants (9.2%, 8.0%, and 4.3% for ages <5 years, 5-9 years, and >10 years; p=0.001). However, only a minority of significantly immunocompromised participants (33%, 26%, and 49% of those with pre-PI CD4% of <5%, 5-14%, or 15-24%) achieved CD4% values above 25%, whereas 84% of those with pre-PI values above 25% maintained such values.Although PI-based therapy was associated with substantial improvements in CD4%, initiation before severe immunosuppression and at younger ages may be more effective for recovery or maintenance of normal CD4%. Randomised investigation of when to start combination therapy in children, particularly infants, is needed." @default.
• W2012377587 created "2016-06-24" @default.
• W2012377587 creator A5017306542 @default.
• W2012377587 creator A5021657274 @default.
• W2012377587 creator A5024029270 @default.
• W2012377587 creator A5033272483 @default.
• W2012377587 creator A5035191354 @default.
• W2012377587 creator A5038269182 @default.
• W2012377587 creator A5041793868 @default.
• W2012377587 creator A5054704639 @default.
• W2012377587 creator A5067906551 @default.
• W2012377587 creator A5068240713 @default.
• W2012377587 creator A5089821583 @default.
• W2012377587 date "2003-12-01" @default.
• W2012377587 modified "2023-10-02" @default.
• W2012377587 title "Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents" @default.
• W2012377587 cites W1494122660 @default.
• W2012377587 cites W1971771720 @default.
• W2012377587 cites W1984423466 @default.
• W2012377587 cites W1996168633 @default.
• W2012377587 cites W2000898504 @default.
• W2012377587 cites W2018122569 @default.
• W2012377587 cites W2025937041 @default.
• W2012377587 cites W2040431789 @default.
• W2012377587 cites W2043122232 @default.
• W2012377587 cites W2045322466 @default.
• W2012377587 cites W2053286376 @default.
• W2012377587 cites W2055603523 @default.
• W2012377587 cites W2056169141 @default.
• W2012377587 cites W2064154402 @default.
• W2012377587 cites W2075230143 @default.
• W2012377587 cites W2082246284 @default.
• W2012377587 cites W2102133068 @default.
• W2012377587 cites W2102145741 @default.
• W2012377587 cites W2102323094 @default.
• W2012377587 cites W2106741340 @default.
• W2012377587 cites W2114699011 @default.
• W2012377587 cites W2119218670 @default.
• W2012377587 cites W2132845988 @default.
• W2012377587 cites W2136160275 @default.
• W2012377587 cites W2144838726 @default.
• W2012377587 cites W2147004263 @default.
• W2012377587 cites W2148825772 @default.
• W2012377587 cites W2155449170 @default.
• W2012377587 cites W2159943759 @default.
• W2012377587 cites W2174240998 @default.
• W2012377587 cites W2330814896 @default.
• W2012377587 cites W2339219218 @default.
• W2012377587 cites W2626177003 @default.
• W2012377587 cites W3088283228 @default.
• W2012377587 cites W4237136736 @default.
• W2012377587 doi "https://doi.org/10.1016/s0140-6736(03)15098-2" @default.
• W2012377587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14697803" @default.
• W2012377587 hasPublicationYear "2003" @default.
• W2012377587 type Work @default.
• W2012377587 sameAs 2012377587 @default.
• W2012377587 citedByCount "68" @default.
• W2012377587 countsByYear W20123775872012 @default.
• W2012377587 countsByYear W20123775872013 @default.
• W2012377587 countsByYear W20123775872014 @default.
• W2012377587 countsByYear W20123775872015 @default.
• W2012377587 countsByYear W20123775872018 @default.
• W2012377587 countsByYear W20123775872019 @default.
• W2012377587 countsByYear W20123775872022 @default.
• W2012377587 countsByYear W20123775872023 @default.
• W2012377587 crossrefType "journal-article" @default.
• W2012377587 hasAuthorship W2012377587A5017306542 @default.
• W2012377587 hasAuthorship W2012377587A5021657274 @default.
• W2012377587 hasAuthorship W2012377587A5024029270 @default.
• W2012377587 hasAuthorship W2012377587A5033272483 @default.
• W2012377587 hasAuthorship W2012377587A5035191354 @default.
• W2012377587 hasAuthorship W2012377587A5038269182 @default.
• W2012377587 hasAuthorship W2012377587A5041793868 @default.
• W2012377587 hasAuthorship W2012377587A5054704639 @default.
• W2012377587 hasAuthorship W2012377587A5067906551 @default.
• W2012377587 hasAuthorship W2012377587A5068240713 @default.
• W2012377587 hasAuthorship W2012377587A5089821583 @default.
• W2012377587 hasConcept C126322002 @default.
• W2012377587 hasConcept C142462285 @default.
• W2012377587 hasConcept C203014093 @default.
• W2012377587 hasConcept C205545832 @default.
• W2012377587 hasConcept C2776090121 @default.
• W2012377587 hasConcept C2776999253 @default.
• W2012377587 hasConcept C2780252810 @default.
• W2012377587 hasConcept C2781143361 @default.
• W2012377587 hasConcept C2993143319 @default.
• W2012377587 hasConcept C2993178667 @default.
• W2012377587 hasConcept C3013748606 @default.
• W2012377587 hasConcept C71924100 @default.
• W2012377587 hasConcept C8891405 @default.
• W2012377587 hasConcept C90924648 @default.
• W2012377587 hasConceptScore W2012377587C126322002 @default.
• W2012377587 hasConceptScore W2012377587C142462285 @default.
• W2012377587 hasConceptScore W2012377587C203014093 @default.
• W2012377587 hasConceptScore W2012377587C205545832 @default.
• W2012377587 hasConceptScore W2012377587C2776090121 @default.
• W2012377587 hasConceptScore W2012377587C2776999253 @default.
• W2012377587 hasConceptScore W2012377587C2780252810 @default.

• next